Oh Wan-Kyu, Kim Sojin, Kwon Ohseok, Jang Jyongsik
World Class University (WCU) Program of Chemical Convergence for Energy & Environment (C2E2), School of Chemical and Biological Engineering, College of Engineering, Seoul National University (SNU), Gwannak_599 Gwannak ro, Gwannak gu, Seoul 151-742, Korea.
J Nanosci Nanotechnol. 2011 May;11(5):4254-60. doi: 10.1166/jnn.2011.3662.
The toxicity of polyaniline (PANI) nanomaterials with four different aspect ratios on human lung fibroblast cells was investigated by cell viability assay, cytotoxicity assay, apoptosis/necrosis measurement, and reactive oxygen species production. The toxicity increased with decreasing aspect ratio of PANI nanomaterials. In contrast, the highest aspect ratio PANI nanomaterials showed similar results with bulk PANI materials. The adverse effect of PANI nanomaterials was also concentration- and time-dependent. Low aspect ratio PANI nanomaterials induced more necrosis and more reactive oxygen species than others. These results provide new understanding of shape-dependent toxicity of nanomaterials.
通过细胞活力测定、细胞毒性测定、凋亡/坏死测量以及活性氧生成，研究了四种不同长径比的聚苯胺（PANI）纳米材料对人肺成纤维细胞的毒性。PANI纳米材料的毒性随长径比的降低而增加。相比之下，长径比最高的PANI纳米材料与块状PANI材料显示出相似的结果。PANI纳米材料的不良影响也具有浓度和时间依赖性。低长径比的PANI纳米材料比其他材料诱导更多的坏死和更多的活性氧。这些结果为纳米材料形状依赖性毒性提供了新的认识。
