Wambua Daniel, Henderson Ryan, Solomon Christopher, Hunter Meredith, Marx Preston, Sette Alessandro, Mothé Bianca R
Department of Biology, California State University, San Marcos, USA.
J Med Primatol. 2011 Aug;40(4):244-7. doi: 10.1111/j.1600-0684.2011.00487.x.
We characterized twelve SIV-infected Chinese-origin rhesus macaques for their entire MHC class I allele composition. Several MHC class I alleles were present in animals with varying outcomes of infections, either elite control or normal progression to AIDS disease. These MHC class I alleles may prove interesting targets for additional characterization.
我们对12只感染了猴免疫缺陷病毒(SIV)的中国恒河猴的整个MHC I类等位基因组成进行了特征分析。在感染结果不同的动物中,即精英控制者或正常进展至艾滋病的动物中,存在几种MHC I类等位基因。这些MHC I类等位基因可能是进行进一步特征分析的有趣靶点。