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感染猴免疫缺陷病毒(SIV)的中国恒河猴在精英控制者或疾病正常进展者中表达特定的主要组织相容性复合体(MHC)I类等位基因。

SIV-infected Chinese-origin rhesus macaques express specific MHC class I alleles in either elite controllers or normal progressors.

作者信息

Wambua Daniel, Henderson Ryan, Solomon Christopher, Hunter Meredith, Marx Preston, Sette Alessandro, Mothé Bianca R

机构信息

Department of Biology, California State University, San Marcos, USA.

出版信息

J Med Primatol. 2011 Aug;40(4):244-7. doi: 10.1111/j.1600-0684.2011.00487.x.

Abstract

We characterized twelve SIV-infected Chinese-origin rhesus macaques for their entire MHC class I allele composition. Several MHC class I alleles were present in animals with varying outcomes of infections, either elite control or normal progression to AIDS disease. These MHC class I alleles may prove interesting targets for additional characterization.

摘要

我们对12只感染了猴免疫缺陷病毒(SIV)的中国恒河猴的整个MHC I类等位基因组成进行了特征分析。在感染结果不同的动物中,即精英控制者或正常进展至艾滋病的动物中,存在几种MHC I类等位基因。这些MHC I类等位基因可能是进行进一步特征分析的有趣靶点。

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