Yamaguchi Prefectural Research Institute of Health, 2-5-67 Aoi, Yamaguchi 753-0821, Japan.
Environ Toxicol Pharmacol. 1998 Dec 1;6(4):217-9. doi: 10.1016/s1382-6689(98)00037-4.
It has been accepted that puffer fish accumulates tetrodotoxin through the food chain. This indicates that tetrodotoxin in puffer fish is exogenous. The present study, however, describes an endogenous origin of tetrodotoxin in puffer fish. For this purpose, the ovulated oocytes from puffer fish Fugu niphobles were artificially fertilized and cultivated. The toxin levels of embryos increased gradually with development until the time of hatching, suggesting that the increased toxin is a product of embryos.
人们已经接受了这样一种观点，即河豚通过食物链积累了河豚毒素。这表明河豚中的河豚毒素是外源性的。然而，本研究描述了河豚中河豚毒素的内源性起源。为此，人工受精和培养了来自暗纹东方鲀的排卵卵母细胞。随着胚胎的发育，毒素水平逐渐增加，直到孵化时，这表明增加的毒素是胚胎的产物。
