居住在西班牙的外国孕妇中的 HTLV 感染。
HTLV infection among foreign pregnant women living in Spain.
机构信息
Infectious Diseases Department, Hospital Carlos III, Calle Sinesio Delgado 10, Madrid, Spain.
出版信息
J Clin Virol. 2011 Oct;52(2):119-22. doi: 10.1016/j.jcv.2011.06.010. Epub 2011 Jul 22.
BACKGROUND
The overall seroprevalence of HTLV infection among pregnant women in Spain is below 0.02% and accordingly universal antenatal screening is not recommended. However, as the number of immigrants has significantly increased during the last decade, this population might warrant specific considerations.
OBJECTIVE
To evaluate the seroprevalence of HTLV infection among immigrant pregnant women living in Spain.
METHODS
From January 2009 to December 2010 a cross-sectional study was carried out in all foreign pregnant women attended at 14 Spanish clinics. All were tested for HTLV antibodies using a commercial enzyme-immunoassay, being reactive samples confirmed by Western blot or PCR.
RESULTS
A total of 3337 foreign pregnant women were examined. Their origin was as follows: Latin America 1579 (47%), North Africa 507 (16%), East Europe 606 (18%), Sub-Saharan Africa 316 (9%), North America and West Europe 116 (3.5%) and Asia and Australia 163 (5%). A total of 7 samples were confirmed as HTLV positive, of which 6 were HTLV-1 and 1 HTLV-2. HTLV-1 infection was found in 5 women coming from Latin America and 1 from Morocco. The only woman with HTLV-2 came from Ghana. The overall HTLV seroprevalence was 0.2%, being 0.3% among Latin Americans and 0.2% among Africans. It was absent among women coming from other regions.
CONCLUSIONS
The seroprevalence of HTLV infection among foreign pregnant women in Spain is 0.2%, being all cases found in immigrants from Latin America and Africa. Given the benefit of preventing vertical transmission, antenatal screening should be recommended in pregnant women coming from these regions.
背景
西班牙孕妇中 HTLV 感染的总体血清流行率低于 0.02%，因此不建议普遍进行产前筛查。然而，在过去十年中，移民人数显著增加，这部分人群可能需要特别考虑。
目的
评估居住在西班牙的移民孕妇中 HTLV 感染的血清流行率。
方法
2009 年 1 月至 2010 年 12 月，对 14 家西班牙诊所的所有外国孕妇进行了一项横断面研究。所有孕妇均采用商业酶免疫分析法检测 HTLV 抗体，阳性样本采用 Western blot 或 PCR 进行确认。
结果
共检查了 3337 名外国孕妇。其原籍如下：拉丁美洲 1579 名（47%），北非 507 名（16%），东欧 606 名（18%），撒哈拉以南非洲 316 名（9%），北美和西欧 116 名（3.5%）和亚洲及澳大利亚 163 名（5%）。共有 7 份样本被确认为 HTLV 阳性，其中 6 份为 HTLV-1，1 份为 HTLV-2。HTLV-1 感染见于 5 名来自拉丁美洲和 1 名来自摩洛哥的女性。唯一的 HTLV-2 感染者来自加纳。HTLV 总血清流行率为 0.2%，拉丁美洲人为 0.3%，非洲人为 0.2%。来自其他地区的女性中未发现 HTLV 感染。
结论
西班牙外国孕妇中 HTLV 感染的血清流行率为 0.2%，所有病例均发现于来自拉丁美洲和非洲的移民中。鉴于预防垂直传播的益处，建议对来自这些地区的孕妇进行产前筛查。
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