Chai F, Raoul G, Wiss A, Ferri J, Hildebrand H F
Université Lille Nord de France, UDSL, 59000 Lille, France.
Rev Stomatol Chir Maxillofac. 2011 Sep;112(4):212-21. doi: 10.1016/j.stomax.2011.06.003. Epub 2011 Jul 23.
Autograft is considered as the "gold standard" for bone reconstruction. It provides osteoinductive factors, osteogenic cells, and appropriate osteoconductive scaffold. Donor site morbidity is the main limitation of autograft. Donor disease transmission limits the use of allograft. Synthetic bone substitutes still lack osteoinductive or osteogenic properties. Composite bone substitutes combining synthetic scaffold and biochemical substances initiating proliferation and cell differentiation, and possibly osteogenesis. Bone substitutes and grafts intended for clinical use are listed.
自体骨移植被视为骨重建的“金标准”。它提供骨诱导因子、成骨细胞和合适的骨传导支架。供体部位并发症是自体骨移植的主要限制因素。供体疾病传播限制了异体骨移植的使用。合成骨替代物仍然缺乏骨诱导或成骨特性。复合骨替代物结合了合成支架和能引发细胞增殖与分化甚至可能促进骨生成的生化物质。列出了用于临床的骨替代物和移植物。
