Department of Plant Pathology, Iowa State University, 351 Bessey Hall, Iowa State University, Ames, IA 50011, USA.
J Bacteriol. 2011 Oct;193(19):5450-64. doi: 10.1128/JB.05262-11. Epub 2011 Jul 22.
Xanthomonas is a large genus of bacteria that collectively cause disease on more than 300 plant species. The broad host range of the genus contrasts with stringent host and tissue specificity for individual species and pathovars. Whole-genome sequences of Xanthomonas campestris pv. raphani strain 756C and X. oryzae pv. oryzicola strain BLS256, pathogens that infect the mesophyll tissue of the leading models for plant biology, Arabidopsis thaliana and rice, respectively, were determined and provided insight into the genetic determinants of host and tissue specificity. Comparisons were made with genomes of closely related strains that infect the vascular tissue of the same hosts and across a larger collection of complete Xanthomonas genomes. The results suggest a model in which complex sets of adaptations at the level of gene content account for host specificity and subtler adaptations at the level of amino acid or noncoding regulatory nucleotide sequence determine tissue specificity.
黄单胞菌是一个大型细菌属，共同导致 300 多种植物物种发病。该属的宿主范围广泛，而个别物种和致病变种的宿主和组织特异性则非常严格。分别感染植物生物学主要模式植物拟南芥和水稻的叶肉组织的黄单胞菌野油菜致病变种 756C 菌株和水稻黄单胞菌致病变种 BLS256 菌株的全基因组序列已被确定，并深入了解了宿主和组织特异性的遗传决定因素。与感染同一宿主维管束组织的密切相关菌株的基因组进行了比较，并对更大的完整黄单胞菌基因组集进行了比较。结果表明，在基因含量水平上的复杂适应集解释了宿主特异性，而在氨基酸或非编码调节核苷酸序列水平上的更细微适应决定了组织特异性。
