铜绿假单胞菌 tssC1 连接六型分泌系统和生物膜特异性抗生素耐药性。
Pseudomonas aeruginosa tssC1 links type VI secretion and biofilm-specific antibiotic resistance.
机构信息
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Room 4125, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5.
出版信息
J Bacteriol. 2011 Oct;193(19):5510-3. doi: 10.1128/JB.00268-11. Epub 2011 Jul 22.
Abstract
Biofilm-specific antibiotic resistance is influenced by multiple factors. We demonstrated that Pseudomonas aeruginosa tssC1, a gene implicated in type VI secretion (T6S), is important for resistance of biofilms to a subset of antibiotics. We showed that tssC1 expression is induced in biofilms and confirmed that tssC1 is required for T6S.
摘要
生物膜特异性抗生素耐药性受多种因素影响。我们证明了铜绿假单胞菌 tssC1 是一种与 VI 型分泌系统（T6S）有关的基因，对生物膜对抗生素亚类的耐药性很重要。我们表明，tssC1 在生物膜中表达被诱导，并证实 tssC1 是 T6S 的必需条件。
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