Smith I C, Princz E J, Saunders J K
Division of Biological Sciences, National Research Council of Canada, Ottawa, Ontario.
Can Assoc Radiol J. 1990 Feb;41(1):32-8.
Magnetic resonance spectroscopy (MRS), a useful complement to magnetic resonance imaging (MRI), yields a wealth of information about the biochemical content of tissue and the dynamic behavior of its component molecules. When used for colonic tumors, it can distinguish between those with and those without metastatic potential, through the relaxation time (T2) of the resonance at 1.3 ppm in the proton (1H) MRS spectrum. The presence of peaks near 3.2 ppm correlates well with tumor stage and allows identification of premalignant tissue. Two-dimensional MRS provides an independent method for staging colonic tumors by means of a crosspeak between 1.3 and 4.2 ppm. With a combination of MRS and MRI (localized spectroscopy) it should soon be possible to locate and stage a colonic tumor without physical intervention. In the plasma of patients who have cancer there often exists a lipoprotein band with MRS characteristics similar to those of colonic tumors. It also occurs occasionally in healthy persons and in those who have diseases other than cancer. The lipoprotein appears to be lipoprotein (a), which also has been associated with cardiac disease. We have used a simple MRS measurement on unfractionated plasma, which has been suggested as a reliable indicator of the presence of cancer, on approximately 1800 persons who were healthy, ill with cancer, and ill with other diseases. We found it unsatisfactory as a screening method for an asymptomatic population, because essentially it measures the plasma triglyceride level, especially that in very low-density lipoprotein, which can be elevated for a variety of reasons unrelated to cancer.
磁共振波谱（MRS）是磁共振成像（MRI）的一种有用补充，可提供有关组织生化成分及其组成分子动态行为的大量信息。用于结肠肿瘤时，它可通过质子（1H）MRS谱中1.3 ppm处共振的弛豫时间（T2）区分具有和不具有转移潜能的肿瘤。3.2 ppm附近峰的存在与肿瘤分期密切相关，可识别癌前组织。二维MRS通过1.3至4.2 ppm之间的交叉峰提供了一种独立的结肠肿瘤分期方法。结合MRS和MRI（局部波谱），不久应能够在无需物理干预的情况下定位和分期结肠肿瘤。癌症患者的血浆中通常存在一条脂蛋白带，其MRS特征与结肠肿瘤相似。它也偶尔出现在健康人和患有非癌症疾病的人身上。这种脂蛋白似乎是脂蛋白（a），它也与心脏病有关。我们对大约1800名健康、患癌症和患其他疾病的人进行了简单的MRS测量，该测量已被建议作为癌症存在的可靠指标。我们发现它作为无症状人群的筛查方法并不令人满意，因为它本质上测量的是血浆甘油三酯水平，尤其是极低密度脂蛋白中的甘油三酯水平，其升高可能有多种与癌症无关的原因。
