Holmes K T, Mackinnon W B, May G L, Wright L C, Dyne M, Tattersall M H, Mountford C E, Sullivan D
Ludwig Institute for Cancer Research (Sydney Branch), University of Sydney, N.S.W., Australia.
NMR Biomed. 1988 Feb;1(1):44-9. doi: 10.1002/nbm.1940010108.
An increase in the plasma levels of apoprotein B-containing lipoproteins is the basis of the magnetic resonance (MR) test for cancer. The narrow MR line width reported by Fossel and co-workers to be associated with the presence of malignant disease is due to a relative increase of very low density lipoprotein. In contrast, the plasma from healthy controls, which has a much broader spectrum, has a higher proportion of high density lipoprotein. However, plasma from patients with hyperlipidemia unrelated to cancer also show narrow MR line widths and are therefore a confounding variable. We used magnetic resonance spectroscopy (MRS) to assess the plasma from 253 patients with a range of lipid related diseases and cancer, and 28 controls. A significant difference (p less than or equal to 0.0005) of 10 Hz exists between the mean line width of the controls and hyperlipidemics without malignant disease. However, in patients with solid tumours a difference of 7 Hz (p less than or equal to 0.0005) in the mean values is recorded although there is an overlap of 6 Hz compared with the controls. Moreover the MRS method was not found to distinguish patients with lymphomas from the control population. The index was not found to be related to patient age or tumour burden.
含载脂蛋白B的脂蛋白血浆水平升高是癌症磁共振（MR）检测的基础。福塞尔及其同事报告称，与恶性疾病存在相关的窄MR线宽是由于极低密度脂蛋白相对增加所致。相比之下，健康对照者的血浆谱更宽，高密度脂蛋白比例更高。然而，与癌症无关的高脂血症患者的血浆也显示出窄MR线宽，因此是一个混杂变量。我们使用磁共振波谱（MRS）评估了253例患有一系列脂质相关疾病和癌症的患者以及28名对照者的血浆。对照者和无恶性疾病的高脂血症患者的平均线宽存在10 Hz的显著差异（p≤0.0005）。然而，在实体瘤患者中，尽管与对照者有6 Hz的重叠，但平均值仍有7 Hz的差异（p≤0.0005）。此外，未发现MRS方法能将淋巴瘤患者与对照人群区分开来。该指标与患者年龄或肿瘤负荷无关。
