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介孔硅在脑膜炎奈瑟菌转化过程中的作用：脑膜炎奈瑟菌转化过程中的环境效应。

Effect of mesoporous silica under Neisseria meningitidis transformation process: environmental effects under meningococci transformation.

机构信息

Department of Biochemistry, Institute of Biology CP6109, State University of Campinas UNICAMP, CP: 6109-CEP 13083-970, Campinas, SP, Brazil.

出版信息

J Nanobiotechnology. 2011 Jul 25;9:28. doi: 10.1186/1477-3155-9-28.

DOI:10.1186/1477-3155-9-28
PMID:21787408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3152511/
Abstract

BACKGROUND

This study aimed the use of mesoporous silica under the naturally transformable Neisseria meningitidis, an important pathogen implicated in the genetic horizontal transfer of DNA causing a escape of the principal vaccination measures worldwide by the capsular switching process. This study verified the effects of mesoporous silica under N. meningitidis transformation specifically under the capsular replacement.

METHODS

we used three different mesoporous silica particles to verify their action in N. meningitis transformation frequency.

RESULTS

we verified the increase in the capsular gene replacement of this bacterium with the three mesoporous silica nanoparticles.

CONCLUSION

the mesouporous silica particles were capable of increasing the capsule replacement frequency in N. meningitidis.

摘要

背景

本研究旨在利用在天然可转化的脑膜炎奈瑟菌中使用介孔二氧化硅，脑膜炎奈瑟菌是一种重要的病原体，其 DNA 的遗传水平转移可导致全球主要的疫苗接种措施失效，原因是荚膜转换过程。本研究验证了介孔二氧化硅在脑膜炎奈瑟菌转化，特别是在荚膜替代中的作用。

方法

我们使用了三种不同的介孔二氧化硅颗粒来验证它们在脑膜炎奈瑟菌转化频率中的作用。

结果

我们验证了这三种介孔纳米粒子增加了细菌的荚膜基因替换。

结论

介孔二氧化硅颗粒能够增加脑膜炎奈瑟菌的荚膜替换频率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/3152511/95419aeadff5/1477-3155-9-28-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/3152511/303054eb423e/1477-3155-9-28-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/3152511/a07999f99103/1477-3155-9-28-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/3152511/ca939ce55795/1477-3155-9-28-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/3152511/92b4d50364c7/1477-3155-9-28-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/3152511/95419aeadff5/1477-3155-9-28-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/3152511/303054eb423e/1477-3155-9-28-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/3152511/a07999f99103/1477-3155-9-28-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/3152511/ca939ce55795/1477-3155-9-28-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/3152511/92b4d50364c7/1477-3155-9-28-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c656/3152511/95419aeadff5/1477-3155-9-28-5.jpg

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