School of Public Health, Wuhan University, Wuhan, Hubei 430071, China.
Environ Toxicol Pharmacol. 2011 Mar;31(2):286-94. doi: 10.1016/j.etap.2010.11.006. Epub 2010 Nov 27.
To evaluate the radiation-protect effects of Laminaria japonica polysaccharides (LJP) on male reproductive system damage and mating dysfunction induced by multiple mini-dose ionizing radiations, male rats were administrated with radiation and/or LJP. Results showed that mating function (such as erection, mount and ejaculation), sperm count and survival rate in LJP group were significantly better than the corresponding model group after the radiation. The testis organ coefficient, GSH (glutathione) content, serum sex hormones (luteinizing hormone, follicle-stimulating hormone, testosterone and estradiol) levels improved while MDA (malondialdehyde) content decreased. In addition, SOD (superoxide dismutase), GSH-PX (glutathione peroxidase), LDH (lactate dehydrogenase) activities were enhanced while testicular tissue damage was reduced, 14 days after the cessation of radiation; all indicators in the LJP group were similar to the control group. Our results suggest that, LJP has some promoting effects on the recovery of the reproductive system and mating dysfunction induced by radiation.
为了评估海带多糖（LJP）对多次小剂量电离辐射引起的雄性生殖系统损伤和交配功能障碍的辐射防护作用，给雄性大鼠进行了辐射和/或 LJP 处理。结果表明，与相应的模型组相比，辐射后 LJP 组的交配功能（如勃起、交配和射精）、精子计数和存活率显著提高。睾丸器官系数、GSH（谷胱甘肽）含量、血清性激素（黄体生成素、卵泡刺激素、睾酮和雌二醇）水平提高，MDA（丙二醛）含量降低。此外，SOD（超氧化物歧化酶）、GSH-PX（谷胱甘肽过氧化物酶）、LDH（乳酸脱氢酶）活性增强，睾丸组织损伤减轻，辐射停止 14 天后；LJP 组的所有指标均与对照组相似。我们的结果表明，LJP 对辐射引起的生殖系统恢复和交配功能障碍有一定的促进作用。
