Faculty of Life Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.
Trends Pharmacol Sci. 2011 Oct;32(10):617-22. doi: 10.1016/j.tips.2011.06.002. Epub 2011 Jul 23.
Inflammation is a complex vascular response that has evolved to eliminate infection and to repair injured tissue. It is subject to tight regulatory control of its initiation and resolution. Failure of an inflammatory response to resolve has become recognised as a major contributor to the pathology of diverse diseases (including acute brain injuries). Interleukin-1 (IL-1) is a pro-inflammatory cytokine and key contributor to damage after acute brain injury. Understanding the regulation of IL-1 production is vital for the development of new drug targets and therapies. In recent years, there have been major advances in how we understand the resolution of inflammatory responses, and in how IL-1 is regulated after injury. Advances are summarised here in the context of addressing how dampening the inflammatory response and actions of IL-1 provides a strategy for reducing damage after acute brain injury such as stroke.
炎症是一种复杂的血管反应，其进化目的是消除感染和修复受损组织。它的起始和解决受到严格的调节控制。炎症反应无法解决已被认为是多种疾病（包括急性脑损伤）病理学的主要原因。白细胞介素-1（IL-1）是一种促炎细胞因子，是急性脑损伤后损伤的关键因素。了解 IL-1 产生的调节对于开发新的药物靶点和治疗方法至关重要。近年来，我们对炎症反应的解决以及损伤后 IL-1 的调节方式有了重大的认识进展。本文在此背景下总结了这些进展，探讨了抑制炎症反应和 IL-1 的作用如何为减轻急性脑损伤（如中风）后的损伤提供策略。
