生物发光成像：进展与应用。
Bioluminescence imaging: progress and applications.
机构信息
Neuroscience Center, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
出版信息
Trends Biotechnol. 2011 Dec;29(12):624-33. doi: 10.1016/j.tibtech.2011.06.010. Epub 2011 Jul 23.
Abstract
Application of bioluminescence imaging has increased tremendously in the past decade and has significantly contributed to core conceptual advances in biomedical research. This technology provides valuable means for monitoring of different biological processes in immunology, oncology, virology and neuroscience. In this review, we discuss current trends in bioluminescence and its application in different fields with an emphasis on cancer research.
摘要
生物发光成像是过去十年中应用增长最快的技术之一，为生物医学研究的核心概念进展做出了重大贡献。该技术为监测免疫学、肿瘤学、病毒学和神经科学中的不同生物学过程提供了有价值的手段。在这篇综述中，我们讨论了生物发光的当前趋势及其在不同领域的应用，重点是癌症研究。
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2
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Gene Ther. 2011 May;18(5):517-27. doi: 10.1038/gt.2010.179. Epub 2011 Feb 17.
3
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Neuro Oncol. 2011 Apr;13(4):384-92. doi: 10.1093/neuonc/noq193. Epub 2011 Feb 11.
4
Potent, tumor-specific gene expression in an orthotopic hepatoma rat model using a Survivin-targeted, amplifiable adenoviral vector.利用 Survivin 靶向、可扩增腺病毒载体在原位肝癌大鼠模型中实现有效的、肿瘤特异性的基因表达。
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