Demirci Senem, Ozsaran Zeynep, Celik Handan Ak, Aras Arif Bulent, Aydin Hikmet Hakan
Department of Radiation Oncology, Ege University Faculty of Medicine, Bornova, Izmir, Turkey.
Tumori. 2011 May-Jun;97(3):290-5. doi: 10.1177/030089161109700306.
To compare the antioxidant status of cervical cancer patients with healthy controls and to assess the antioxidant levels before and after radiotherapy or radiochemotherapy.
Antioxidant levels (glutathione, glutathione peroxidase, superoxide dismutase, and malondialdehyde) were measured in 35 patients with cervical cancer and 35 age-matched healthy controls. Blood samples were collected twice (before and after treatment) from cervical cancer patients and once from healthy control subjects.
In the patient group, pre-radiotherapy glutathione and glutathione peroxidase levels were significantly lower (P <0.01 and P <0.0001, respectively) than the control group. Pre-radiotherapy levels of superoxide dismutase were significantly higher in cancer patients (P <0.01). In general, no difference was observed between pre- and post-radiotherapy antioxidant levels in cancer patients. However, when post-radiotherapy glutathione levels were analyzed, patients who did not respond to treatment had significantly higher levels than those who did respond (P <0.01).
Levels of antioxidants significantly differed between the patients with cervical cancer and the controls, and no change in antioxidant levels was observed after treatment. Moreover, further studies evaluating the predictive value of glutathione levels on treatment response are warranted.
比较宫颈癌患者与健康对照者的抗氧化状态，并评估放疗或放化疗前后的抗氧化水平。
测定35例宫颈癌患者和35例年龄匹配的健康对照者的抗氧化水平（谷胱甘肽、谷胱甘肽过氧化物酶、超氧化物歧化酶和丙二醛）。从宫颈癌患者中采集两次血样（治疗前后），从健康对照者中采集一次血样。
在患者组中，放疗前谷胱甘肽和谷胱甘肽过氧化物酶水平显著低于对照组（分别为P<0.01和P<0.0001）。癌症患者放疗前超氧化物歧化酶水平显著更高（P<0.01）。总体而言，癌症患者放疗前后的抗氧化水平未观察到差异。然而，分析放疗后谷胱甘肽水平时，未对治疗产生反应的患者水平显著高于有反应的患者（P<0.01）。
宫颈癌患者与对照者的抗氧化水平存在显著差异，治疗后抗氧化水平未观察到变化。此外，有必要进一步研究评估谷胱甘肽水平对治疗反应的预测价值。
