Bhuvarahamurthy V, Balasubramanian N, Govindasamy S
Department of Biochemistry, University of Madras, India.
Mol Cell Biochem. 1996 May 10;158(1):17-23. doi: 10.1007/BF00225878.
Circulating lipid peroxide, antioxidant components and the activities of defense enzymes were estimated in uterine cervical carcinoma patients (before and after radiotherapy and radiotherapy combined chemotherapy) and compared with controls. Some of the antioxidant components such as glutathione, vitamin E and selenium are reduced in cervical cancer. The reduced levels of vitamin E and glutathione were normalized after treatment. Erythrocyte lipid peroxide (E-LPx) and erythrocyte membrane lipid peroxide (EM-LPx) levels were found to be increased in all the stages of uterine cervical carcinoma. The important antioxidant enzymes such as erythrocyte superoxide dismutase (E-SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST) and glucose-6-phosphate dehydrogenase (G6PDH) were found to be decreased in uterine cervical carcinoma. These altered biochemical parameters were reversed to normal, of course with varied degree after different mode of therapy. Significant normalization was observed in Type II chemoradiotherapy.
对子宫颈癌患者（放疗前、放疗后以及放疗联合化疗后）的循环脂质过氧化物、抗氧化成分及防御酶活性进行了评估，并与对照组进行比较。宫颈癌患者体内的一些抗氧化成分，如谷胱甘肽、维生素E和硒有所减少。治疗后维生素E和谷胱甘肽水平降低的情况恢复正常。发现在子宫颈癌的所有阶段，红细胞脂质过氧化物（E-LPx）和红细胞膜脂质过氧化物（EM-LPx）水平均升高。子宫颈癌患者体内重要的抗氧化酶，如红细胞超氧化物歧化酶（E-SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-Px）、谷胱甘肽-S-转移酶（GST）和葡萄糖-6-磷酸脱氢酶（G6PDH）均减少。这些改变的生化参数在不同治疗方式后当然会不同程度地恢复正常。在II型放化疗中观察到显著恢复正常。
