Bortolini Maria Augusta Tezelli, Rizk Diaa E E
Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Gynecology, Federal University of São Paulo, Borges Lagoa, 783 Cj. 31, 04038-031, São Paulo, SP, Brazil.
Int Urogynecol J. 2011 Oct;22(10):1211-9. doi: 10.1007/s00192-011-1502-4. Epub 2011 Jul 26.
An increasing number of scientists have studied the molecular and biochemical basis of pelvic organ prolapse (POP). The extracellular matrix content of the pelvic floor is the major focus of those investigations and pointed for potential molecular markers of the dysfunction. The identification of women predisposed to develop POP would help in the patients' management and care. This article includes a critical analysis of the literature up to now; discusses implications for future research and the role of the genetics in POP.
越来越多的科学家研究了盆腔器官脱垂（POP）的分子和生化基础。盆底的细胞外基质成分是这些研究的主要焦点，并指出了功能障碍的潜在分子标志物。识别易患POP的女性将有助于患者的管理和护理。本文对迄今为止的文献进行了批判性分析；讨论了对未来研究的影响以及遗传学在POP中的作用。
