Institut Pasteur, Paris, France.
Emerg Infect Dis. 2011 Aug;17(8):1364-70. doi: 10.3201/eid1708.110278.
While studying the virome of the skin surface of a patient with a Merkel cell carcinoma (MCC) by using unbiased, high-throughput sequencing, we identified a human polyomavirus nearly identical to human polyomavirus 9, a virus recently reported in blood and urine of renal transplantion patients and closely related to the African green monkey lymphotropic polyomavirus. Specific PCR analysis further identified this virus in 2/8 patients with MCC but in only 1/111 controls without MCC. This virus was shed for ≥20 months by the MCC index patient and was on the skin of the spouse of the index patient. These results provide information on the viral ecology of human skin and raise new questions regarding the pathology of virus-associated skin disorders.
在通过无偏、高通量测序研究一名 Merkel 细胞癌 (MCC) 患者皮肤表面的病毒组时，我们发现了一种与人多瘤病毒 9 几乎完全相同的病毒，该病毒最近在肾移植患者的血液和尿液中被报道，与非洲绿猴嗜淋巴多瘤病毒密切相关。特定的 PCR 分析进一步在 2/8 名 MCC 患者中但仅在 1/111 名无 MCC 的对照中鉴定出这种病毒。这种病毒被 MCC 指数患者至少排出了 20 个月，并存在于指数患者的配偶的皮肤上。这些结果提供了有关人类皮肤病毒生态学的信息，并提出了有关病毒相关皮肤疾病病理学的新问题。
