探寻PUF蛋白识别RNA的缺失密码。
Finding the missing code of RNA recognition by PUF proteins.
作者信息
Chen Yu, Varani Gabriele
机构信息
Department of Chemistry, University of Washington, Seattle, WA 98195, USA.
出版信息
Chem Biol. 2011 Jul 29;18(7):821-3. doi: 10.1016/j.chembiol.2011.07.001.
Abstract
Pumilio and FBF homology (PUF) proteins represent highly promising candidates for engineering sequence-specific RNA recognition, but were only known to recognize G, A, and U, significantly limiting applications. Two groups (Filipovska et al., 2011; Dong et al., 2011) have now reported the discovery of the cytosine-recognition code for PUF proteins.
摘要
Pumilio和FBF同源（PUF）蛋白是工程化序列特异性RNA识别中极具潜力的候选蛋白，但此前仅知其能识别鸟嘌呤（G）、腺嘌呤（A）和尿嘧啶（U），这极大地限制了其应用。现在有两个研究小组（菲利波夫斯卡等人，2011年；董等人，2011年）报告了PUF蛋白胞嘧啶识别密码的发现。
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