造血干细胞和祖细胞的归巢。
Hematopoietic stem and progenitor cell trafficking.
机构信息
Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
出版信息
Trends Immunol. 2011 Oct;32(10):493-503. doi: 10.1016/j.it.2011.06.011. Epub 2011 Jul 29.
Abstract
Migration of hematopoietic stem cells (HSCs) is essential during embryonic development and throughout adult life. During embryogenesis, trafficking of HSCs is responsible for the sequential colonization of different hematopoietic organs by blood-producing cells. In adulthood, circulation of HSCs maintains homeostasis of the hematopoietic system and participates in innate immune responses. HSC trafficking is also crucial in clinical settings such as bone marrow (BM) and stem cell transplantation. This review provides an overview of the molecular and cellular signals that control and fine-tune trafficking of HSCs and hematopoietic progenitor cells in embryogenesis and during postnatal life. We also discuss the potential clinical utility of therapeutic approaches to modulate HSC trafficking in patients.
摘要
造血干细胞（HSCs）的迁移在胚胎发育和整个成年期都是至关重要的。在胚胎发生过程中，HSCs 的运输负责血液生成细胞依次定殖不同的造血器官。在成年期，HSCs 的循环维持造血系统的内稳态，并参与先天免疫反应。HSC 运输在骨髓（BM）和干细胞移植等临床环境中也至关重要。本综述概述了控制和微调 HSCs 和造血祖细胞在胚胎发生和出生后生命中运输的分子和细胞信号。我们还讨论了在患者中调节 HSC 运输的治疗方法的潜在临床应用。
相似文献
1
Hematopoietic stem and progenitor cell trafficking.造血干细胞和祖细胞的归巢。
Trends Immunol. 2011 Oct;32(10):493-503. doi: 10.1016/j.it.2011.06.011. Epub 2011 Jul 29.
2
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche.骨髓 CD169+ 巨噬细胞促进造血干细胞和祖细胞在间充质干细胞龛中的滞留。
J Exp Med. 2011 Feb 14;208(2):261-71. doi: 10.1084/jem.20101688. Epub 2011 Jan 31.
3
In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice.子宫内胎儿造血干细胞的耗竭可改善小鼠新生儿移植后的植入情况。
Blood. 2014 Aug 7;124(6):973-80. doi: 10.1182/blood-2014-02-550327. Epub 2014 May 30.
4
Expansive effects of aorta-gonad-mesonephros-derived stromal cells on hematopoietic stem cells from embryonic stem cells.主动脉-性腺-中肾来源的基质细胞对胚胎干细胞来源的造血干细胞的扩增作用。
Chin Med J (Engl). 2005 Dec 5;118(23):1979-86.
5
Comparison of toxicity of benzene metabolite hydroquinone in hematopoietic stem cells derived from murine embryonic yolk sac and adult bone marrow.比较苯代谢物对羟苯在来源于鼠胚胎卵黄囊和成年骨髓的造血干细胞中的毒性。
PLoS One. 2013 Aug 5;8(8):e71153. doi: 10.1371/journal.pone.0071153. Print 2013.
6
[Comparative study of human fetal and adult bone marrow derived mesenchymal stem cells].人胎儿与成人骨髓间充质干细胞的比较研究
Zhonghua Xue Ye Xue Za Zhi. 2002 Dec;23(12):645-8.
7
Expansion and preservation of the functional activity of adult hematopoietic stem cells cultured ex vivo with a histone deacetylase inhibitor.使用组蛋白去乙酰化酶抑制剂体外培养成年造血干细胞时其功能活性的扩展与保存
Stem Cells Transl Med. 2020 Apr;9(4):531-542. doi: 10.1002/sctm.19-0199. Epub 2020 Jan 17.
8
Mesenchymal stromal cells: radio-resistant members of the bone marrow.间质基质细胞：骨髓中的辐射抗性成员。
Immunol Cell Biol. 2013 Jan;91(1):5-11. doi: 10.1038/icb.2012.61. Epub 2012 Nov 20.
9
Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver.内皮细胞蛋白 C 受体表达的造血干细胞位于胎肝窦周隙龛内。
Blood. 2010 Jul 29;116(4):544-53. doi: 10.1182/blood-2009-08-240903. Epub 2010 May 4.
10
The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche.内质网伴侣蛋白 GRP94 对于维持造血干细胞与成年骨髓龛的相互作用是必需的。
PLoS One. 2011;6(5):e20364. doi: 10.1371/journal.pone.0020364. Epub 2011 May 24.
引用本文的文献
1
Microwells as Minimalistic Niches to Study Heterotypic Interactions of Stromal and Hematopoietic Stem Cells.作为研究基质细胞和造血干细胞异型相互作用的简约微环境的微孔
Methods Mol Biol. 2025;2939:65-82. doi: 10.1007/7651_2025_628.
2
An SSTR2-somatostatin chemotactic axis drives T cell progenitor homing to the intestines.SSTR2-生长抑素趋化轴驱动T细胞祖细胞归巢至肠道。
Nat Immunol. 2025 Apr;26(4):607-618. doi: 10.1038/s41590-025-02097-8. Epub 2025 Mar 26.
3
The role of the haematopoietic stem cell niche in development and ageing.造血干细胞微环境在发育和衰老中的作用。
Nat Rev Mol Cell Biol. 2025 Jan;26(1):32-50. doi: 10.1038/s41580-024-00770-8. Epub 2024 Sep 10.
4
Chimeric Cell Therapies as a Novel Approach for Duchenne Muscular Dystrophy (DMD) and Muscle Regeneration.嵌合细胞疗法作为一种治疗杜氏肌营养不良症（DMD）和肌肉再生的新方法。
Biomolecules. 2024 May 13;14(5):575. doi: 10.3390/biom14050575.
5
Bitter Taste Receptor Agonist Denatonium Inhibits Stemness Characteristics in Hematopoietic Stem/Progenitor Cells.苦味受体激动剂苯甲地那铵抑制造血干/祖细胞的干性特征。
Stem Cells. 2024 Jan 13;42(1):42-54. doi: 10.1093/stmcls/sxad075.
6
Phenotypical changes of hematopoietic stem and progenitor cells in COVID-19 patients: Correlation with disease status.COVID-19患者造血干细胞和祖细胞的表型变化：与疾病状态的相关性。
Cent Eur J Immunol. 2023;48(2):97-110. doi: 10.5114/ceji.2023.129981. Epub 2023 Jul 17.
7
Mechanism and effects of extramedullary hematopoiesis on anti-tumor immunity.髓外造血对抗肿瘤免疫的机制及影响
Cancer Biol Med. 2023 Jul 24;20(7):477-82. doi: 10.20892/j.issn.2095-3941.2023.0203.
8
CXCR4 Recognition by L- and D-Peptides Containing the Full-Length V3 Loop of HIV-1 gp120.CXCR4 的识别由包含全长 HIV-1 gp120 V3 环的 L-和 D-肽引起。
Viruses. 2023 Apr 28;15(5):1084. doi: 10.3390/v15051084.
9
Nuclear Tubulin Enhances CXCR4 Transcription and Promotes Chemotaxis Through TCF12 Transcription Factor in human Hematopoietic Stem Cells.核微管蛋白通过 TCF12 转录因子增强人造血干/祖细胞中 CXCR4 的转录并促进趋化作用。
Stem Cell Rev Rep. 2023 Jul;19(5):1328-1339. doi: 10.1007/s12015-023-10543-z. Epub 2023 Apr 17.
10
Akt isoforms in the immune system.免疫系统中的 Akt 同工型。
Front Immunol. 2022 Aug 23;13:990874. doi: 10.3389/fimmu.2022.990874. eCollection 2022.
本文引用的文献
1
The role of sphingosine 1-phosphate in migration of osteoclast precursors; an application of intravital two-photon microscopy.鞘氨醇 1-磷酸在破骨细胞前体细胞迁移中的作用；体内双光子显微镜的应用。
Mol Cells. 2011 May;31(5):399-403. doi: 10.1007/s10059-011-1010-x. Epub 2011 Feb 25.
2
Embryonic origin of the adult hematopoietic system: advances and questions.成人造血系统的胚胎起源：进展与问题。
Development. 2011 Mar;138(6):1017-31. doi: 10.1242/dev.040998.
3
Hematopoietic progenitor migration to the adult thymus.造血祖细胞向成人胸腺的迁移。
Ann N Y Acad Sci. 2011 Jan;1217:122-38. doi: 10.1111/j.1749-6632.2010.05881.x. Epub 2011 Jan 11.
4
G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands.G-CSF 介导体外血小板生成素释放通过诱导 Cxcr2 配体触发中性粒细胞从骨髓中的迁移和动员。
Blood. 2011 Apr 21;117(16):4349-57. doi: 10.1182/blood-2010-09-308387. Epub 2011 Jan 11.
5
Pharmacologic modulation of the calcium-sensing receptor enhances hematopoietic stem cell lodgment in the adult bone marrow.钙敏感受体的药理学调节增强了造血干细胞在成年骨髓中的定植。
Blood. 2011 Jan 27;117(4):1167-75. doi: 10.1182/blood-2010-05-286294. Epub 2010 Nov 12.
6
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche.间充质和造血干细胞构成了独特的骨髓龛。
Nature. 2010 Aug 12;466(7308):829-34. doi: 10.1038/nature09262.
7
Phenotypically identical hemopoietic stem cells isolated from different regions of bone marrow have different biologic potential.表型相同的造血干细胞从骨髓的不同区域分离出来，具有不同的生物学潜能。
Blood. 2010 Oct 28;116(17):3185-96. doi: 10.1182/blood-2009-12-260703. Epub 2010 Jul 14.
8
Haematopoietic stem cells derive directly from aortic endothelium during development.造血干细胞在发育过程中直接来源于主动脉内皮。
Nature. 2010 Mar 4;464(7285):108-11. doi: 10.1038/nature08738. Epub 2010 Feb 14.
9
Blood stem cells emerge from aortic endothelium by a novel type of cell transition.血液干细胞通过一种新型的细胞转变从主动脉内皮中出现。
Nature. 2010 Mar 4;464(7285):112-5. doi: 10.1038/nature08761. Epub 2010 Feb 14.
10
In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium.从鼠主动脉内皮细胞中出现的造血细胞的体内成像。
Nature. 2010 Mar 4;464(7285):116-20. doi: 10.1038/nature08764. Epub 2010 Feb 14.
Zotero 插件