Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.
Cell Metab. 2011 Aug 3;14(2):154-60. doi: 10.1016/j.cmet.2011.06.013.
Dietary restriction (DR) and mutations in nutrient signaling pathways can extend healthy life span in diverse organisms. Studying the interaction between these interventions should reveal mechanisms of aging, but has yielded some apparently contradictory results. A multidimensional representation of nutrition, called the geometric framework, can better describe the responses of life span and other traits, including metabolism, and can reconcile these apparent contradictions. We provide examples showing that it is more informative to analyze DR in terms of dietary balance and that dietary optimization for life span is critical for studies examining the biology of aging and other traits.
饮食限制（DR）和营养信号通路的突变可以延长多种生物的健康寿命。研究这些干预措施之间的相互作用应该可以揭示衰老的机制，但却产生了一些明显矛盾的结果。一种称为几何框架的多维营养表示形式可以更好地描述寿命和其他特征（包括新陈代谢）的反应，并可以调和这些明显的矛盾。我们提供的例子表明，根据饮食平衡来分析 DR 更具信息量，并且对于研究衰老生物学和其他特征的研究来说，优化饮食以延长寿命是至关重要的。
