Jin Chun Xiang, Hayakawa Tetsuo, Ko Shigeru B H, Ishiguro Hiroshi, Kitagawa Motoji
The First Clinical College of Norman Bethune Medical Division, Jilin University, China.
Intern Med. 2011;50(15):1507-16. doi: 10.2169/internalmedicine.50.5362. Epub 2011 Aug 1.
Pancreatic stone protein (PSP; reported in 1979), pancreatitis-associated protein (PAP; 1984) and regenerating protein (Reg I; 1988) were discovered independently in the fields of the exocrine (pancreatitis) and endocrine (diabetes) pancreas. Subsequent analysis revealed that PSP and Reg I are identical and PAP belongs to the same protein family. PSP/Reg I and PAP share a selective and specific trypsin cleavage site and result in insoluble fibrils (PTP, PATP). Search for a functional role of PSP had led to the idea that it might serve as an inhibitor in pancreatic stone formation and PSP was renamed lithostathine. Inhibitory effects of lithostathine in stone formation have been questioned. Evidence so far obtained can support a lithogenic role rather than a lithostatic role of PSP. PAP and its isoforms have been investigated mainly regarding responses to inflammation and stress. Reg I and its isoforms have been examined on regeneration, growth and mitogenesis in gastrointestinal neoplastic diseases as well as diabetes. Evidence obtained can be applied in the prediction of prognosis and therapy for inflammatory and neoplastic diseases.
胰石蛋白（PSP；1979年报道）、胰腺炎相关蛋白（PAP；1984年）和再生蛋白（Reg I；1988年）分别在外分泌胰腺（胰腺炎）和内分泌胰腺（糖尿病）领域被独立发现。随后的分析表明，PSP和Reg I是相同的，且PAP属于同一蛋白家族。PSP/Reg I和PAP具有一个选择性且特异性的胰蛋白酶切割位点，并会形成不溶性纤维（PTP、PATP）。对PSP功能作用的探索引发了一种观点，即它可能在胰石形成中起抑制剂作用，因此PSP被重新命名为抑石素。抑石素在结石形成中的抑制作用受到了质疑。目前所获得的证据支持PSP具有致石作用而非抑石作用。对PAP及其同工型的研究主要集中在对炎症和应激的反应方面。Reg I及其同工型已在胃肠道肿瘤疾病以及糖尿病的再生、生长和有丝分裂方面进行了研究。所获得的证据可应用于炎症性疾病和肿瘤性疾病的预后预测及治疗。
