Department of Surgery and Transplantation, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
Pancreatology. 2020 Apr;20(3):301-304. doi: 10.1016/j.pan.2020.01.016. Epub 2020 Feb 1.
Pancreatic stone protein (PSP), discovered in the 1970ies, was first associated with stone formation during chronic pancreatitis. Later, the same protein was independently detected in islet preparations and named regenerating protein 1 (REG1). Additional isoforms of PSP, including pancreatitis-associated protein (PAP), belong to the same protein family. Although the names indicate a potential function in stone formation or islet regeneration, involvements in cellular processes were only suggestive and never unequivocally proven. We established an association between PSP levels in patient blood samples and the development of sepsis. In this review, written in connection with receiving the Lifetime Achievement Award of the European Pancreatic Club, the evolution of the sepsis aspect of PSP is described. We conclude that the true functional properties of this fascinating pancreatic protein still remain an enigma.
胰腺分泌蛋白（PSP）于 20 世纪 70 年代被发现，最初与慢性胰腺炎时的结石形成有关。后来，在胰岛制剂中独立检测到相同的蛋白质，并将其命名为再生蛋白 1（REG1）。PSP 的其他同工型，包括胰腺炎相关蛋白（PAP），属于同一蛋白家族。尽管这些名称表明其在结石形成或胰岛再生中具有潜在功能，但在细胞过程中的作用只是提示性的，从未被明确证实。我们发现患者血液样本中的 PSP 水平与脓毒症的发展之间存在关联。在本文中，我们描述了 PSP 与脓毒症方面的关联，这是在获得欧洲胰腺俱乐部终身成就奖之际撰写的。我们的结论是，这种引人入胜的胰腺蛋白的真正功能特性仍然是一个谜。
