Department of Bacteriology, University Hospital of Dijon, BP 37013, 21070 Dijon Cedex, France.
Antimicrob Agents Chemother. 2011 Oct;55(10):4912-4. doi: 10.1128/AAC.00341-11. Epub 2011 Aug 1.
Achromobacter xylosoxidans is an emerging pathogen in cystic fibrosis patients. The multidrug resistance of these bacteria remains poorly understood. We have characterized in a clinical strain the first resistance-nodulation-cell division (RND)-type multidrug efflux pump in this species: AxyABM. The inactivation of the transporter component axyB gene led to decreased MICs of cephalosporins (except cefepime), aztreonam, nalidixic acid, fluoroquinolones, and chloramphenicol.
木糖氧化无色杆菌是囊性纤维化患者中一种新兴的病原体。这些细菌的多药耐药性仍知之甚少。我们在临床菌株中鉴定了该物种的第一个耐药性-结节性细胞分裂（RND）型多药外排泵：AxyABM。转运蛋白成分axyB 基因的失活导致头孢菌素（除头孢吡肟外）、氨曲南、萘啶酸、氟喹诺酮类和氯霉素的 MIC 值降低。
