首株木糖氧化无色杆菌 RND 型多重耐药外排泵 AxyABM 的描述。
First description of an RND-type multidrug efflux pump in Achromobacter xylosoxidans, AxyABM.
机构信息
Department of Bacteriology, University Hospital of Dijon, BP 37013, 21070 Dijon Cedex, France.
出版信息
Antimicrob Agents Chemother. 2011 Oct;55(10):4912-4. doi: 10.1128/AAC.00341-11. Epub 2011 Aug 1.
Abstract
Achromobacter xylosoxidans is an emerging pathogen in cystic fibrosis patients. The multidrug resistance of these bacteria remains poorly understood. We have characterized in a clinical strain the first resistance-nodulation-cell division (RND)-type multidrug efflux pump in this species: AxyABM. The inactivation of the transporter component axyB gene led to decreased MICs of cephalosporins (except cefepime), aztreonam, nalidixic acid, fluoroquinolones, and chloramphenicol.
摘要
木糖氧化无色杆菌是囊性纤维化患者中一种新兴的病原体。这些细菌的多药耐药性仍知之甚少。我们在临床菌株中鉴定了该物种的第一个耐药性-结节性细胞分裂（RND）型多药外排泵：AxyABM。转运蛋白成分axyB 基因的失活导致头孢菌素（除头孢吡肟外）、氨曲南、萘啶酸、氟喹诺酮类和氯霉素的 MIC 值降低。
相似文献
1
First description of an RND-type multidrug efflux pump in Achromobacter xylosoxidans, AxyABM.首株木糖氧化无色杆菌 RND 型多重耐药外排泵 AxyABM 的描述。
Antimicrob Agents Chemother. 2011 Oct;55(10):4912-4. doi: 10.1128/AAC.00341-11. Epub 2011 Aug 1.
2
Innate aminoglycoside resistance of Achromobacter xylosoxidans is due to AxyXY-OprZ, an RND-type multidrug efflux pump.木糖氧化无色杆菌固有氨基糖苷类耐药性归因于 AxyXY-OprZ，一种 RND 型多药外排泵。
Antimicrob Agents Chemother. 2013 Jan;57(1):603-5. doi: 10.1128/AAC.01243-12. Epub 2012 Oct 22.
3
Role of AxyABM overexpression in acquired resistance in Achromobacter xylosoxidans.AxyABM 过表达在木糖氧化无色杆菌获得性耐药中的作用。
J Antimicrob Chemother. 2022 Mar 31;77(4):926-929. doi: 10.1093/jac/dkab479.
4
Efflux pump genes of the resistance-nodulation-division family in Burkholderia cenocepacia genome.洋葱伯克霍尔德菌基因组中耐药-结瘤-分裂家族的外排泵基因。
BMC Microbiol. 2006 Jul 20;6:66. doi: 10.1186/1471-2180-6-66.
5
AcGI1, a novel genomic island carrying antibiotic resistance integron In687 in multidrug resistant Achromobacter xylosoxidans in a teaching hospital in Thailand.泰国一所教学医院中多重耐药的木糖氧化无色杆菌携带抗生素耐药整合子 In687 的新型基因组岛 AcGI1。
FEMS Microbiol Lett. 2020 Jul 1;367(14). doi: 10.1093/femsle/fnaa109.
6
Characterisation of OXA-258 enzymes and AxyABM efflux pump in Achromobacter ruhlandii.在鲁氏不动杆菌中对 OXA-258 酶和 AxyABM 外排泵的特性分析。
J Glob Antimicrob Resist. 2018 Sep;14:233-237. doi: 10.1016/j.jgar.2018.03.015. Epub 2018 Apr 9.
7
Fluoroquinolone-resistant Achromobacter xylosoxidans clinical isolates from Serbia: high prevalence of the aac-(6')-Ib-cr gene among resistant isolates.来自塞尔维亚的耐氟喹诺酮类木糖氧化无色杆菌临床分离株：耐药分离株中aac-(6')-Ib-cr基因的高流行率
Folia Microbiol (Praha). 2019 Mar;64(2):153-159. doi: 10.1007/s12223-018-0639-7. Epub 2018 Aug 13.
8
Genomic insights into intrinsic and acquired drug resistance mechanisms in Achromobacter xylosoxidans.木糖氧化无色杆菌内在和获得性耐药机制的基因组学见解
Antimicrob Agents Chemother. 2015 Feb;59(2):1152-61. doi: 10.1128/AAC.04260-14. Epub 2014 Dec 8.
9
Achromobacter xylosoxidans: an emerging pathogen carrying different elements involved in horizontal genetic transfer.木糖氧化无色杆菌：一种携带不同水平基因转移相关元件的新兴病原体。
Curr Microbiol. 2012 Dec;65(6):673-8. doi: 10.1007/s00284-012-0213-5. Epub 2012 Aug 28.
10
Role of AxyZ Transcriptional Regulator in Overproduction of AxyXY-OprZ Multidrug Efflux System in Achromobacter Species Mutants Selected by Tobramycin.AxyZ转录调节因子在妥布霉素筛选的无色杆菌属突变体中AxyXY-OprZ多药外排系统过量产生中的作用
Antimicrob Agents Chemother. 2017 Jul 25;61(8). doi: 10.1128/AAC.00290-17. Print 2017 Aug.
引用本文的文献
1
Description of Two Resistance-Nodulation-Cell Division Efflux Systems Involved in Acquired Antibiotic Resistance: AxySUV in and AinCDJ in .参与获得性抗生素耐药性的两种耐药-结瘤-细胞分裂外排系统的描述：嗜水气单胞菌中的AxySUV和[具体菌名未给出]中的AinCDJ 。
Antibiotics (Basel). 2025 May 23;14(6):536. doi: 10.3390/antibiotics14060536.
2
Highly carbapenem-resistant harboring in Myanmar.在缅甸发现的高度耐碳青霉烯类菌株。 （原英文表述不太完整准确，推测完整意思后翻译，仅供参考）
Microbiol Spectr. 2025 Jul;13(7):e0008025. doi: 10.1128/spectrum.00080-25. Epub 2025 May 19.
3
AMRrounds: susceptibility-so it goes.抗菌药物耐药性巡诊：药敏情况就是如此。
JAC Antimicrob Resist. 2024 Sep 20;6(5):dlae134. doi: 10.1093/jacamr/dlae134. eCollection 2024 Oct.
4
Unraveling antibiotic resistance in IA strain: genomic insights, structural analysis, and prospects for targeted therapeutics.解析侵袭性曲霉（IA）菌株中的抗生素耐药性：基因组学见解、结构分析及靶向治疗前景
Microbiol Spectr. 2024 Oct 29;12(12):e0392623. doi: 10.1128/spectrum.03926-23.
5
Comprehensive analysis of microbiome biodiversity in popular date palm (Phoenix dactylifera L.) fruit varieties.对常见的枣椰果品种（Phoenix dactylifera L.）微生物组多样性的综合分析。
Sci Rep. 2024 Sep 5;14(1):20658. doi: 10.1038/s41598-024-71249-x.
6
A case of community-acquired spondylodiscitis caused by .一例由……引起的社区获得性脊椎椎间盘炎病例。 （原文此处病因缺失）
IDCases. 2024 Apr 30;36:e01980. doi: 10.1016/j.idcr.2024.e01980. eCollection 2024.
7
Genetic and Biochemical Characterization of AXC-2 from .来自……的AXC-2的遗传与生化特性分析 （你提供的原文不完整，这里补充了部分内容使翻译更符合逻辑）
Pathogens. 2024 Jan 27;13(2):115. doi: 10.3390/pathogens13020115.
8
Susceptibility of Species Isolated from Cystic Fibrosis Patients: a 6-Year Survey.从囊性纤维化患者中分离出的 种属的易感性：一项 6 年调查。
Antimicrob Agents Chemother. 2023 Jul 18;67(7):e0037923. doi: 10.1128/aac.00379-23. Epub 2023 Jun 13.
9
Isolation, identification, and drug resistance of a partially isolated bacterium from the gill of .从……鳃部部分分离出的一种细菌的分离、鉴定及耐药性
Open Life Sci. 2023 Jun 6;18(1):20220608. doi: 10.1515/biol-2022-0608. eCollection 2023.
10
Polymyxin Resistance and Heteroresistance Are Common in Clinical Isolates of Species and Correlate with Modifications of the Lipid A Moiety of Lipopolysaccharide.多黏菌素耐药性和异质性耐药在 种的临床分离株中很常见，与脂多糖脂质 A 部分的修饰有关。
Microbiol Spectr. 2023 Feb 14;11(1):e0372922. doi: 10.1128/spectrum.03729-22. Epub 2022 Dec 15.
本文引用的文献
1
Inflammation in Achromobacter xylosoxidans infected cystic fibrosis patients.在患有囊性纤维化的阿罗卡伯氏菌感染患者中的炎症反应。
J Cyst Fibros. 2010 Jan;9(1):51-8. doi: 10.1016/j.jcf.2009.10.005. Epub 2009 Nov 25.
2
In vitro susceptibility of Achromobacter spp. isolates: comparison of disk diffusion, Etest and agar dilution methods.体外鉴定不动杆菌属分离株的药敏情况：纸片扩散法、Etest 法和琼脂稀释法的比较。
Int J Antimicrob Agents. 2010 Jan;35(1):68-71. doi: 10.1016/j.ijantimicag.2009.08.015. Epub 2009 Nov 4.
3
Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms.耐抗菌假单胞菌：染色体编码耐药机制的临床影响和复杂调节。
Clin Microbiol Rev. 2009 Oct;22(4):582-610. doi: 10.1128/CMR.00040-09.
4
Respiratory microbiology of patients with cystic fibrosis in the United States, 1995 to 2005.1995年至2005年美国囊性纤维化患者的呼吸道微生物学
Chest. 2009 Dec;136(6):1554-1560. doi: 10.1378/chest.09-0132. Epub 2009 Jun 8.
5
Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans.木糖氧化无色杆菌天然存在的D类β-内酰胺酶的特性分析
Antimicrob Agents Chemother. 2008 Jun;52(6):1952-6. doi: 10.1128/AAC.01463-07. Epub 2008 Mar 24.
6
Characterization of bacterial operons consisting of two tubulins and a kinesin-like gene by the novel Two-Step Gene Walking method.通过新型两步基因步移法对由两个微管蛋白和一个类驱动蛋白基因组成的细菌操纵子进行表征。
Nucleic Acids Res. 2007;35(20):e135. doi: 10.1093/nar/gkm836. Epub 2007 Oct 16.
7
Urinary tract infection due to Achromobacter xylosoxidans: report of 9 cases.木糖氧化无色杆菌引起的尿路感染：9例报告
Scand J Infect Dis. 2008;40(2):84-7. doi: 10.1080/00365540701558714.
8
VEB-1 in Achromobacter xylosoxidans from cystic fibrosis patient, France.来自法国囊性纤维化患者嗜麦芽窄食单胞菌中的VEB-1。
Emerg Infect Dis. 2006 Nov;12(11):1737-9. doi: 10.3201/eid1211.060143.
9
Achromobacter xylosoxidans in cystic fibrosis: prevalence and clinical relevance.木糖氧化无色杆菌在囊性纤维化中的情况：患病率及临床相关性
J Cyst Fibros. 2007 Jan;6(1):75-8. doi: 10.1016/j.jcf.2006.05.011. Epub 2006 Jun 21.
10
VIM-2 metallo-beta-lactamase in Achromobacter xylosoxidans in Europe.欧洲木糖氧化无色杆菌中的VIM-2金属β-内酰胺酶
Eur J Clin Microbiol Infect Dis. 2005 Dec;24(12):854-5. doi: 10.1007/s10096-005-0054-2.
Zotero 插件