Mustaffa F, Indurkar J, Ismail S, Mordi M N, Ramanathan S, Mansor S M
Centre for Drug Research, Universiti Sains Malaysia, 11800, Penang, Malaysia.
Pharmacognosy Res. 2010 Mar;2(2):76-81. doi: 10.4103/0974-8490.62952.
Cinnomomum iners standardized leaves methanolic extract (CSLE) was subjected to analgesic, toxicity and phytochemical studies. The analgesic activity of CSLE was evaluated using formalin, hot plate and tail flick tests at doses of 100, 200 and 500 mg/kg. CSLE showed significant activity (P < 0.05) in the formalin model (late phase) on the rats at doses of 200 and 500 mg/kg. However, CSLE did not show activity in the hot plate and tail flick tests. The results obtained suggest that CSLE acts peripherally to relieve pain. For the toxicity study, CSLE was orally administered to the Swiss albino mice according to the Organization for Economic Co-Operation and Development (OECD) guideline 423. There was no lethality or toxic symptoms observed for all the tested doses throughout the 14-day period. Phytochemical screening of CSLE showed the presence of cardiac glycoside, flavonoid, polyphenol, saponin, sugar, tannin and terpenoid.
对阴香标准化叶片甲醇提取物（CSLE）进行了镇痛、毒性和植物化学研究。采用福尔马林、热板和甩尾试验，以100、200和500mg/kg的剂量评估CSLE的镇痛活性。CSLE在200和500mg/kg剂量下对大鼠福尔马林模型（后期）显示出显著活性（P<0.05）。然而，CSLE在热板和甩尾试验中未显示出活性。所得结果表明，CSLE通过外周作用来缓解疼痛。在毒性研究中，根据经济合作与发展组织（OECD）指南423，将CSLE口服给予瑞士白化小鼠。在整个14天期间，所有测试剂量均未观察到致死性或毒性症状。CSLE的植物化学筛选显示存在强心苷、黄酮类、多酚、皂苷、糖、单宁和萜类化合物。
