Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, 300 UCLA Medical Plaza, University of California, Los Angeles, California 90095-7076, USA.
Nat Rev Immunol. 2011 Aug 5;11(9):625-32. doi: 10.1038/nri3042.
Innate immune responses are regulated by microorganisms and cell death, as well as by a third class of stress signal from the nervous and endocrine systems. The innate immune system also feeds back, through the production of cytokines, to regulate the function of the central nervous system (CNS), and this has effects on behaviour. These signals provide an extrinsic regulatory circuit that links physiological, social and environmental conditions, as perceived by the CNS, with transcriptional 'decision-making' in leukocytes. CNS-mediated regulation of innate immune responses optimizes total organism fitness and provides new opportunities for therapeutic control of chronic infectious, inflammatory and neuropsychiatric diseases.
先天免疫反应受微生物和细胞死亡的调节，也受来自神经系统和内分泌系统的第三类应激信号的调节。先天免疫系统还通过细胞因子的产生进行反馈，调节中枢神经系统 (CNS) 的功能，从而影响行为。这些信号提供了一种外在的调节回路，将 CNS 感知到的生理、社会和环境条件与白细胞中的转录“决策”联系起来。CNS 介导的先天免疫反应的调节优化了机体的整体适应性，并为慢性感染、炎症和神经精神疾病的治疗控制提供了新的机会。
