呼肠孤病毒感染后细胞溶解性T淋巴细胞的产生：S1基因的作用
Generation of cytolytic T lymphocytes after reovirus infection: role of S1 gene.
作者信息
Finberg R, Weiner H L, Fields B N, Benacerraf B, Burakoff S J
出版信息
Proc Natl Acad Sci U S A. 1979 Jan;76(1):442-6. doi: 10.1073/pnas.76.1.442.
Abstract
Cytotoxic T lymphocytes (CTLs) can be generated if spleen cells from reovirus-infected mice are stimulated in vitro with syngeneic reovirus-infected cells. These cytolytic effector cells demonstrate: (i) serotype specificity (i.e., maximal cytolytic activity is observed on target cells infected with the serotype used to induce the CTLs) and (ii) H-2 restriction. The SI gene was shown to be the predominant viral gene determining the specificity of the cytotoxic T cells. This genome segment has previously been demonstrated to encode the viral hemagglutinin and determines reovirus cell tropism in the nervous system.
摘要
如果用同基因呼肠孤病毒感染的细胞在体外刺激呼肠孤病毒感染小鼠的脾细胞，就可以产生细胞毒性T淋巴细胞（CTL）。这些溶细胞效应细胞表现出：（i）血清型特异性（即在用其诱导CTL的血清型感染的靶细胞上观察到最大的溶细胞活性）和（ii）H-2限制性。SI基因被证明是决定细胞毒性T细胞特异性的主要病毒基因。此前已证明该基因组片段编码病毒血凝素，并决定呼肠孤病毒在神经系统中的细胞嗜性。
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