呼肠孤病毒感染后细胞溶解性T淋巴细胞的产生：S1基因的作用
Generation of cytolytic T lymphocytes after reovirus infection: role of S1 gene.
作者信息
Finberg R, Weiner H L, Fields B N, Benacerraf B, Burakoff S J
出版信息
Proc Natl Acad Sci U S A. 1979 Jan;76(1):442-6. doi: 10.1073/pnas.76.1.442.
Abstract
Cytotoxic T lymphocytes (CTLs) can be generated if spleen cells from reovirus-infected mice are stimulated in vitro with syngeneic reovirus-infected cells. These cytolytic effector cells demonstrate: (i) serotype specificity (i.e., maximal cytolytic activity is observed on target cells infected with the serotype used to induce the CTLs) and (ii) H-2 restriction. The SI gene was shown to be the predominant viral gene determining the specificity of the cytotoxic T cells. This genome segment has previously been demonstrated to encode the viral hemagglutinin and determines reovirus cell tropism in the nervous system.
摘要
如果用同基因呼肠孤病毒感染的细胞在体外刺激呼肠孤病毒感染小鼠的脾细胞，就可以产生细胞毒性T淋巴细胞（CTL）。这些溶细胞效应细胞表现出：（i）血清型特异性（即在用其诱导CTL的血清型感染的靶细胞上观察到最大的溶细胞活性）和（ii）H-2限制性。SI基因被证明是决定细胞毒性T细胞特异性的主要病毒基因。此前已证明该基因组片段编码病毒血凝素，并决定呼肠孤病毒在神经系统中的细胞嗜性。
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本文引用的文献
1
Reoviruses. A new group of respiratory and enteric viruses formerly classified as ECHO type 10 is described.呼肠孤病毒。描述了一组新的呼吸道和肠道病毒，以前被归类为埃可病毒10型。
Science. 1959 Nov 20;130(3386):1387-9. doi: 10.1126/science.130.3386.1387.
2
3
Inhibition of cell-mediated cytolysis of trinitrophenyl-derivatized target cells by alloantisera directed to the products of the K and D loci of the H-2 complex.针对H-2复合体K和D位点产物的同种抗血清对三硝基苯基衍生化靶细胞的细胞介导细胞溶解作用的抑制。
Proc Natl Acad Sci U S A. 1976 Feb;73(2):625-9. doi: 10.1073/pnas.73.2.625.
4
Neutralization of reovirus: the gene responsible for the neutralization antigen.呼肠孤病毒的中和作用：负责中和抗原的基因。
J Exp Med. 1977 Nov 1;146(5):1305-10. doi: 10.1084/jem.146.5.1305.
5
Genome RNAs and polypeptides of reovirus serotypes 1, 2, and 3.呼肠孤病毒1、2和3型的基因组RNA及多肽
J Virol. 1977 Jun;22(3):726-33. doi: 10.1128/JVI.22.3.726-733.1977.
6
Early presence of ribonucleoprotein antigen on surface of influenza virus-infected cells.核糖核蛋白抗原在流感病毒感染细胞表面的早期存在。
Nature. 1977 Mar 3;266(5597):52-4. doi: 10.1038/266052a0.
7
H-2 compatibility requirement for virus-specific T cell-mediated effector functions in vivo. I. Specificity of T cells conferring antiviral protection against lymphocytic choriomeningitis virus is associated with H-2K and H-2D.体内病毒特异性T细胞介导的效应功能对H-2兼容性的要求。I. 赋予抗淋巴细胞性脉络丛脑膜炎病毒抗病毒保护作用的T细胞特异性与H-2K和H-2D相关。
J Immunol. 1976 Nov;117(5 Pt 1):1495-502.
8
A genetic map of reovirus. II. Assignment of the double-stranded RNA-negative mutant groups C, D, and E to genome segments.呼肠孤病毒的遗传图谱。II. 双链RNA阴性突变体C、D和E组在基因组片段上的定位
Virology. 1978 Apr;85(2):531-4. doi: 10.1016/0042-6822(78)90459-2.
9
A genetic map of reovirus. 1. Correlation of genome RNAs between serotypes 1, 2, and 3.
Virology. 1978 Jan;84(1):63-74. doi: 10.1016/0042-6822(78)90218-0.
10
Identification of the gene coding for the hemagglutinin of reovirus.呼肠孤病毒血凝素编码基因的鉴定。
Virology. 1978 May 15;86(2):581-4. doi: 10.1016/0042-6822(78)90099-5.
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