脂联素基因与结直肠癌风险。
Adiponectin gene and risk of colorectal cancer.
机构信息
Department of Human Genetics, University of Michigan School of Medicine, 1524 BSRB, 109 Zina Pitcher, Ann Arbor, MI, USA.
出版信息
Br J Cancer. 2011 Aug 9;105(4):562-4. doi: 10.1038/bjc.2011.259.
BACKGROUND
Genes of the adiponectin pathway are interesting candidates for colorectal cancer risk based on the potential association between colorectal cancer and obesity. However, variants of the adiponectin gene (ADIPOQ) have been demonstrated to be inconsistently associated with risk of colorectal cancer.
METHODS
The current study attempted to evaluate these findings by examining several single nucleotide polymorphisms (SNPs) that were previously genotyped as part of a genome-wide association study in the ADIPOQ gene. Genotyping was also performed for a previously reported risk variant, rs266729, in 1062 individuals with a diagnosis of colorectal cancer and 1062 controls matched on age, gender and ethnicity (Jewish or not Jewish) as part of a population-based case-control study in Israel.
RESULTS
No evidence was found for an association between ADIPOQ and risk of colorectal cancer. The single nucleotide variant previously associated with decreased risk of colorectal cancer, rs266729, revealed an adjusted odds ratio of 1.04; 95% confidence interval, 0.88-1.23.
CONCLUSION
The SNP, rs266729, was not strongly associated with colorectal cancer in patients of Ashkenazi Jewish descent or other ethnic groups in Israel.
背景
脂肪细胞因子通路的基因是结直肠癌风险的候选基因，因为结直肠癌与肥胖之间存在潜在的关联。然而，脂肪细胞因子基因 (ADIPOQ) 的变异与结直肠癌的风险并不一致。
方法
本研究试图通过检查 ADIPOQ 基因中以前作为全基因组关联研究一部分进行基因分型的几个单核苷酸多态性 (SNP) 来评估这些发现。还对之前报道的风险变异 rs266729 进行了基因分型，该变异是在以色列的一项基于人群的病例对照研究中，对 1062 名结直肠癌患者和 1062 名年龄、性别和种族（犹太或非犹太）匹配的对照者进行了检测。
结果
没有证据表明 ADIPOQ 与结直肠癌风险之间存在关联。先前与结直肠癌风险降低相关的单核苷酸变异 rs266729 显示校正后的比值比为 1.04；95%置信区间，0.88-1.23。
结论
在以色列的阿什肯纳兹犹太裔或其他族裔的患者中，SNP rs266729 与结直肠癌的相关性并不强。
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