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手术中边界机械连接的大的IV期黄斑裂孔视网膜色素上皮缺损的长期减少。

Long-term decrease of retinal pigment epithelium defects in large stage iv macular holes with borders mechanically joined during surgery.

作者信息

Michalewska Zofia, Michalewski Janusz, Nawrocki Jerzy

机构信息

Ophthalmic Clinic 'Jasne Blonia', Lodz, Poland.

出版信息

Case Rep Ophthalmol. 2011 May;2(2):215-21. doi: 10.1159/000330553. Epub 2011 Jul 25.

DOI:10.1159/000330553
PMID:21829404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3150968/
Abstract

PURPOSE

The aim of this paper is to present retinal pigment epithelium (RPE) defects in spectral domain optical coherence tomography (SD-OCT) and their gradual resolution over time.

MATERIALS AND METHODS

Observational case series of 3 eyes of 3 patients who were followed for a period of 3-6 years after undergoing surgery to mechanically close the borders of large stage IV macular holes. Photoreceptor defects and RPE defects were measured during this period with SD-OCT.

RESULTS

In all cases, a reduction in the size of the areas of photoreceptor and RPE defects was noted, which correlated with late improvement in visual acuity (VA).

CONCLUSIONS

In eyes with no underlying retinal pigment epithelial or choroidal disease, restoration of RPE is possible in vivo for up to several years after surgery for macular hole closure. An improvement in VA is possible, even lasting many years after successful macular hole surgery, which corresponds to a decrease in both RPE defects and the size of the defects in the junction between the inner and outer segments of photoreceptors.

摘要

目的

本文旨在呈现光谱域光学相干断层扫描（SD - OCT）中视网膜色素上皮（RPE）缺损情况及其随时间的逐渐恢复。

材料与方法

对3例患者的3只眼进行观察性病例系列研究，这些患者在接受手术机械性封闭IV期大黄斑裂孔边缘后随访3 - 6年。在此期间用SD - OCT测量光感受器缺损和RPE缺损情况。

结果

在所有病例中，均观察到光感受器和RPE缺损区域大小减小，这与视力（VA）的后期改善相关。

结论

在无潜在视网膜色素上皮或脉络膜疾病的眼中，黄斑裂孔封闭术后数年内，RPE在体内有可能恢复。黄斑裂孔手术成功后，视力有可能改善，甚至持续多年，这与RPE缺损以及光感受器内外节交界处缺损大小的减小相对应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2a4/3150968/9029c1f3bffd/cop0002-0215-f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2a4/3150968/aed6dc46ffef/cop0002-0215-f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2a4/3150968/9029c1f3bffd/cop0002-0215-f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2a4/3150968/aed6dc46ffef/cop0002-0215-f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2a4/3150968/9029c1f3bffd/cop0002-0215-f02.jpg

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Graefes Arch Clin Exp Ophthalmol. 2010 Sep;248(9):1249-55. doi: 10.1007/s00417-010-1370-5. Epub 2010 Apr 9.
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