Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8514, Japan.
J Nat Prod. 2011 Aug 26;74(8):1812-6. doi: 10.1021/np2001286. Epub 2011 Aug 10.
A green pigment, viridaphin A₁ glucoside (1), was isolated from the green aphid Megoura crassicauda. One- and two-dimensional NMR spectrometric analyses of 1 and its aglycone established the structure as an octacyclic compound. Viridaphin A₁ glucoside exhibited cytotoxicity against HL-60 human tumor cells with an IC₅₀ of 23 μM and antibacterial activity against Bacillus subtilis NBRC 3134 with a minimum inhibitory concentration of 10.0 μg/mL. These results suggested that aphid pigments may protect aphids from invasive species, including viruses and bacteria.
从绿色蚜虫 Megoura crassicauda 中分离得到一种绿色色素，即绿啶 A1 葡萄糖苷（1）。通过对 1 及其苷元的一维和二维 NMR 光谱分析，确定其结构为一个八环化合物。绿啶 A1 葡萄糖苷对 HL-60 人肿瘤细胞表现出细胞毒性，IC50 为 23 μM，对枯草芽孢杆菌 NBRC 3134 表现出抗菌活性，最小抑菌浓度为 10.0 μg/mL。这些结果表明，蚜虫色素可能保护蚜虫免受包括病毒和细菌在内的入侵物种的侵害。
