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[肾细胞癌:2010年有哪些新进展?]

[Renal cell carcinoma: what is new in 2010?].

作者信息

Tsaur I, Haferkamp A

机构信息

Klinik für Urologie und Kinderurologie, Universitätsklinik, Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, Frankfurt am Main, Germany.

出版信息

Urologe A. 2011 Sep;50 Suppl 1:216-8. doi: 10.1007/s00120-011-2676-6.

DOI:10.1007/s00120-011-2676-6
PMID:21837489
Abstract

This overview presents new insights into renal cell carcinoma (RCC). The search for new target structures for targeted therapy as well as diagnostic and prognostic markers continues to remain a desirable area of research. Investigations are focusing on the use of well-established and new therapeutic agents for metastatic RCC and an increasingly liberal indication for organ-sparing surgery for renal tumors. The response to systemic treatment in metastatic RCC is also being evaluated in defined subpopulations.

摘要

本综述介绍了肾细胞癌(RCC)的新见解。寻找靶向治疗的新靶点结构以及诊断和预后标志物仍然是一个理想的研究领域。研究重点在于将成熟的和新型治疗药物用于转移性RCC,以及对肾肿瘤采取越来越宽松的保留器官手术指征。转移性RCC对全身治疗的反应也正在特定亚群中进行评估。

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1
[Renal cell carcinoma: what is new in 2010?].[肾细胞癌:2010年有哪些新进展?]
Urologe A. 2011 Sep;50 Suppl 1:216-8. doi: 10.1007/s00120-011-2676-6.
2
[Renal cell carcinoma].[肾细胞癌]
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本文引用的文献

1
Partial nephrectomy does not compromise survival in patients with pathologic upstaging to pT2/pT3 or high-grade renal tumors compared with radical nephrectomy.与根治性肾切除术相比,部分肾切除术不会影响病理分期为 pT2/pT3 或高级别肾肿瘤患者的生存。
Urology. 2011 May;77(5):1142-6. doi: 10.1016/j.urology.2010.11.058. Epub 2011 Mar 21.
2
Evaluation of response to multikinase inhibitor in metastatic renal cell carcinoma by FDG PET/contrast-enhanced CT.采用 FDG PET/对比增强 CT 评估转移性肾细胞癌对多激酶抑制剂的反应。
Clin Nucl Med. 2010 Dec;35(12):918-23. doi: 10.1097/RLU.0b013e3181f9ddd9.
3
A prospective, randomised EORTC intergroup phase 3 study comparing the oncologic outcome of elective nephron-sparing surgery and radical nephrectomy for low-stage renal cell carcinoma.
一项前瞻性、随机、EORTC 多组间 3 期研究比较了选择性保留肾单位手术和根治性肾切除术治疗低分期肾细胞癌的肿瘤学结局。
Eur Urol. 2011 Apr;59(4):543-52. doi: 10.1016/j.eururo.2010.12.013. Epub 2010 Dec 22.
4
Oncologic long-term outcome of elective nephron-sparing surgery versus radical nephrectomy in patients with renal cell carcinoma stage pT1b or greater in a matched-pair cohort.在匹配对队列中,对于 T1b 期及以上肾细胞癌患者,选择行保留肾单位手术与根治性肾切除术的肿瘤学长期结局比较。
Urology. 2011 Apr;77(4):803-8. doi: 10.1016/j.urology.2010.09.020. Epub 2010 Dec 8.
5
Sunitinib rechallenge in metastatic renal cell carcinoma patients.舒尼替尼二线治疗转移性肾细胞癌。
Cancer. 2010 Dec 1;116(23):5400-6. doi: 10.1002/cncr.25583. Epub 2010 Nov 2.
6
Active treatment of localized renal tumors may not impact overall survival in patients aged 75 years or older.对于 75 岁及以上的患者,局部肾肿瘤的积极治疗可能不会影响总体生存率。
Cancer. 2010 Jul 1;116(13):3119-26. doi: 10.1002/cncr.25184.
7
Comparison of warm ischemia versus no ischemia during partial nephrectomy on a solitary kidney.对比孤立肾部分切除术时热缺血与无缺血的效果。
Eur Urol. 2010 Sep;58(3):331-6. doi: 10.1016/j.eururo.2010.05.048. Epub 2010 Jun 9.
8
Phase 3 trial of everolimus for metastatic renal cell carcinoma : final results and analysis of prognostic factors.依维莫司治疗转移性肾细胞癌的 3 期临床试验:最终结果和预后因素分析。
Cancer. 2010 Sep 15;116(18):4256-65. doi: 10.1002/cncr.25219.
9
Partial nephrectomy is associated with improved overall survival compared to radical nephrectomy in patients with unanticipated benign renal tumours.与根治性肾切除术相比,部分肾切除术与意外良性肾肿瘤患者的总生存率提高相关。
Eur Urol. 2010 Aug;58(2):293-8. doi: 10.1016/j.eururo.2010.04.033. Epub 2010 May 18.
10
Quality of life in patients with advanced renal cell carcinoma treated with temsirolimus or interferon-alpha.接受替西罗莫司或干扰素-α治疗的晚期肾细胞癌患者的生活质量。
Br J Cancer. 2010 May 11;102(10):1456-60. doi: 10.1038/sj.bjc.6605647.