Division of Oncology, Rambam Health Care Campus and Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Obes Surg. 2011 Nov;21(11):1792-7. doi: 10.1007/s11695-011-0490-2.
It is a well-known fact that severe obesity is associated with the metabolic syndrome, type 2 diabetes, cardiovascular disease, hypertension, and other diseases. Epidemiological studies have suggested that obesity is also associated with increased risk of several cancer types. The number of people who are suffering from severe obesity is growing, and clinical data suggest that severely obese patients belong to a unique population with regards to risk, efficacy of screening, and cancer treatment. This review will point out the potential mechanism linking obesity and cancer and will discuss several challenges in various treatment modalities of cancer in obese patients.
一个众所周知的事实是，严重肥胖与代谢综合征、2 型糖尿病、心血管疾病、高血压和其他疾病有关。流行病学研究表明，肥胖还与多种癌症类型的风险增加有关。患有严重肥胖症的人数正在增加，临床数据表明，严重肥胖患者在风险、筛查效果和癌症治疗方面属于一个独特的群体。本综述将指出肥胖与癌症之间的潜在机制，并讨论肥胖患者在各种癌症治疗方式中面临的几个挑战。
