通过 C-H 活化实现分子复杂性：一种脱氢 Diels-Alder 反应。
Molecular complexity via C-H activation: a dehydrogenative Diels-Alder reaction.
机构信息
Roger Adams Laboratory, Department of Chemistry, University of Illinois, Urbana, Illinois 61801, United States.
出版信息
J Am Chem Soc. 2011 Sep 28;133(38):14892-5. doi: 10.1021/ja2059704. Epub 2011 Sep 1.
Abstract
Traditionally, C-H oxidation reactions install oxidized functionality onto a preformed molecular skeleton, resulting in a local molecular change. The use of C-H activation chemistry to construct complex molecular scaffolds is a new area with tremendous potential in synthesis. We report a Pd(II)/bis-sulfoxide-catalyzed dehydrogenative Diels-Alder reaction that converts simple terminal olefins into complex cycloadducts in a single operation.
摘要
传统上，C-H 氧化反应在预先形成的分子骨架上安装氧化官能团，导致局部分子变化。利用 C-H 活化化学构建复杂的分子支架是合成中具有巨大潜力的新领域。我们报告了一种 Pd(II)/双砜催化的脱氢 Diels-Alder 反应，该反应可将简单的末端烯烃在一步反应中转化为复杂的环加成产物。
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