Braun M, Perner S
Institut für Pathologie, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Deutschland.
Pathologe. 2011 Nov;32 Suppl 2:237-41. doi: 10.1007/s00292-011-1500-9.
For many tumors the early detection of precursor lesions of invasive cancer has an impact on the clinical course. The high-grade prostatic intraepithelial neoplasia (HG-PIN) is the only accepted facultative precursor lesion for acinar prostate cancer. While HG-PIN shows many similarities to prostate cancer it is most probably not a precursor of every prostate cancer variant. However, the detection of HG-PIN in needle biopsies is a significant risk factor for the subsequent diagnosis of invasive prostate cancer. Low-grade PIN (LG-PIN), proliferative inflammatory atrophy (PIA), and atypical adenomatous hyperplasia are no longer considered to be true precursor lesions.
对于许多肿瘤而言，浸润性癌前体病变的早期检测会影响临床病程。高级别前列腺上皮内瘤变（HG-PIN）是腺泡状前列腺癌唯一被认可的潜在前体病变。虽然HG-PIN与前列腺癌有许多相似之处，但它很可能并非每种前列腺癌变体的前体。然而，在针吸活检中检测到HG-PIN是随后诊断浸润性前列腺癌的一个重要风险因素。低级别PIN（LG-PIN）、增殖性炎性萎缩（PIA）和非典型腺瘤样增生不再被认为是真正的前体病变。
