Xu Lin-Ya, Quan Xue-Sheng, Wang Chen, Sheng Hui-Fang, Zhou Guang-Xiong, Lin Bi-Run, Jiang Ren-Wang, Yao Xin-Sheng
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, China.
J Antibiot (Tokyo). 2011 Oct;64(10):661-665. doi: 10.1038/ja.2011.65. Epub 2011 Aug 17.
Two new antimycin antibiotics; that is antimycins A(19) (1) and A(20) (2), were isolated from a cultured broth of marine actinomycete Streptomyces antibioticus H74-18 together with antimycins A(1a) (3a) and A(1b) (3b), A(2a) (4), A(3a) (5a) and A(3b) (5b). Their structures were determined by spectroscopic methods in combination with X-ray diffraction. Antimycin A(19) possessed a chiral acyl chain and an alkyl branch. The absolute configuration of chiral acyl chain in 1 was determined by X-ray diffraction analysis. Antimycin A(20) (2) has the shortest and simplest acetoxy acyl chain in the antimycins family. All the antimycins (1-5) showed potential antifungal activities against Candida albicans with MIC of about 5-10 μg ml(-1).
从海洋放线菌抗生链霉菌H74-18的培养液中分离出两种新的抗霉素抗生素，即抗霉素A(19)（1）和A(20)（2），同时还分离出抗霉素A(1a)（3a）、A(1b)（3b）、A(2a)（4）、A(3a)（5a）和A(3b)（5b）。通过光谱方法结合X射线衍射确定了它们的结构。抗霉素A(19)具有一个手性酰基链和一个烷基支链。通过X射线衍射分析确定了1中手性酰基链的绝对构型。抗霉素A(20)（2）在抗霉素家族中具有最短且最简单的乙酰氧基酰基链。所有抗霉素（1-5）对白色念珠菌均显示出潜在的抗真菌活性，其最低抑菌浓度约为5-10μg/ml。
