Department of Paediatric Dentistry, School of Dentistry, University of Naples 'Federico II', Naples, Italy.
Int Dent J. 2011 Aug;61(4):210-6. doi: 10.1111/j.1875-595X.2011.00059.x.
Casein phosphopeptide-amorphous calcium phosphate nanocomplexes (CPP-ACP) exhibit anticariogenic potential in laboratory, animal and human experiments. The remineralising potential of synthetic CPPs on early enamel caries was investigated.
In vivo study.
University of Naples 'Federico II', School of Dentistry, Department of Paediatric Dentistry, 2010, Italy.
40 volunteers (age range 10-16 years) were recruited and divided in two groups of 20 (Group A and B).
In Group A subjects two demineralised enamel specimens were placed on the buccal surfaces of the first molars and subjects were instructed to apply a commercial product containing CPPs (GC Tooth Mousse) only on the right-sided specimen and a placebo mousse on the left, for 1 month. In Group B subjects two enamel specimens were similarly placed into the mouth and used as controls.
SEM analysis revealed a diffuse and homogeneous mineral coating, reducing the surface alterations only in the demineralised specimens treated with synthetic CPPs into the mouth.
Results demonstrate that CPPs are able to promote remineralisation of early enamel lesions.
酪蛋白磷酸肽-无定形磷酸钙纳米复合物（CPP-ACP）在实验室、动物和人体实验中表现出抗龋潜力。本研究旨在研究合成 CPP 对早期釉质龋的再矿化潜力。
体内研究。
意大利那不勒斯费德里克二世大学牙科学院儿童牙科系，2010 年。
招募了 40 名志愿者（年龄在 10-16 岁之间），并将其分为两组，每组 20 人（A 组和 B 组）。
在 A 组中，将两个脱矿釉质标本放置在第一磨牙的颊面，指示受试者仅在右侧标本上使用含有 CPP 的商业产品（GC Tooth Mousse），而在左侧标本上使用安慰剂慕斯，为期 1 个月。在 B 组中，将两个釉质标本同样放入口腔中作为对照。
SEM 分析显示，一种弥散且均匀的矿物质涂层，仅在口腔中用合成 CPP 处理的脱矿标本上减少了表面变化。
结果表明 CPP 能够促进早期釉质病变的再矿化。
