Friis-Christiansen P, Thiel S, Svehag S E, Dessau R, Svendsen P, Andersen O, Laursen S B, Jensenius J C
Department of Clinical Microbiology, Institute of Medical Microbiology, Odense University, Denmark.
Scand J Immunol. 1990 Apr;31(4):453-60. doi: 10.1111/j.1365-3083.1990.tb02792.x.
Conglutinin is a mammalian C-type lectin which agglutinates iC3b-coated erythrocytes. Ingram [13] found that euglobulin from bovine serum may confer partial protection against experimental infections in mice. We now present evidence that the protective activity in euglobulin against infections of BALB/c mice with Salmonella typhimurium is mediated by conglutinin. Conglutinin also demonstrated antibacterial activity against E. coli and S. typhimurium in vitro. The expression of this activity required the presence of heat-labile serum factors and peritoneal exudate or spleen cells, but not antibodies to the bacteria. Antibacterial activity was also demonstrated when the bacteria were pretreated with serum at 37 degrees C before incubation with conglutinin and cells. The activity of conglutinin was not observed when factor I-deficient or EDTA-treated serum was used instead of normal serum. The active peritoneal exudate or spleen cells showed adherence to plastic.
胶固素是一种哺乳动物C型凝集素，可凝集被iC3b包被的红细胞。英格拉姆[13]发现，牛血清优球蛋白可对小鼠实验性感染提供部分保护。我们现在提供证据表明，优球蛋白对BALB/c小鼠抵抗鼠伤寒沙门氏菌感染的保护活性是由胶固素介导的。胶固素在体外也表现出对大肠杆菌和鼠伤寒沙门氏菌的抗菌活性。这种活性的表达需要不耐热血清因子以及腹膜渗出液或脾细胞的存在，但不需要针对细菌的抗体。当细菌在与胶固素和细胞孵育前用37℃血清预处理时，也表现出抗菌活性。当使用因子I缺陷型或经EDTA处理的血清代替正常血清时，未观察到胶固素的活性。有活性的腹膜渗出液或脾细胞表现出对塑料的黏附性。
