Zhao Weian, Teo Grace Sock Leng, Kumar Namit, Karp Jeffrey M
Harvard-MIT Division of Heath Sciences and Technology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School Harvard Stem Cell Institute, 65 Landsdowne Street, Cambridge, MA 02139, USA.
Mater Today (Kidlington). 2010 Apr;13(4):14-21. doi: 10.1016/S1369-7021(10)70056-0.
Cell surfaces are fertile ground for chemists and material scientists to manipulate or augment cell functions and phenotypes. This not only helps to answer basic biology questions but also has diagnostic and therapeutic applications. In this review, we summarize the most recent advances in the engineering of the cell surface. In particular, we focus on the potential applications of surface engineered cells for 1) targeting cells to desirable sites in cell therapy, 2) programming assembly of cells for tissue engineering, 3) bioimaging and sensing, and ultimately 4) manipulating cell biology.
细胞表面是化学家与材料科学家操控或增强细胞功能及表型的理想领域。这不仅有助于解答基础生物学问题，还具有诊断和治疗应用价值。在本综述中，我们总结了细胞表面工程的最新进展。特别地，我们聚焦于表面工程细胞在以下方面的潜在应用：1）在细胞治疗中将细胞靶向至理想位点；2）为组织工程对细胞进行编程组装；3）生物成像与传感；以及最终4）操控细胞生物学。
