Sansone Randy A, Sansone Lori A
Dr. R. Sansone is a professor in the Departments of Psychiatry and Internal Medicine at Wright State University School of Medicine in Dayton, Ohio, and Director of Psychiatry Education at Kettering Medical Center in Kettering, Ohio.
Innov Clin Neurosci. 2011 Jul;8(7):12-7.
In this article, the authors examine the preponderance of publications pertaining to relationships between allergies and anxiety and mood syndromes. Through a review of the relevant articles in the PubMed and PsycINFO databases, the authors found that the majority of studies (9 of 11 studies on anxiety syndromes, 10 of 12 studies on depressive syndromes) indicate associations between allergies and anxiety/mood syndromes, despite a number of methodological variances. In addition, there appear to be a number of potential variables that mediate the relationship between allergies and these two psychiatric phenomena (e.g., allergies may heighten risk for these syndromes by triggering the immune system and cytokines; allergies may impair sleep through nasal obstruction and secondarily exacerbate psychiatric symptoms; and allergies may negatively affect cognitive functioning and contribute to psychiatric disturbance) as well as a possible shared genetic risk. The authors review and discuss these variables.
在本文中，作者研究了与过敏症和焦虑及情绪综合征之间关系相关的出版物的优势情况。通过回顾PubMed和PsycINFO数据库中的相关文章，作者发现，尽管存在一些方法上的差异，但大多数研究（关于焦虑综合征的11项研究中有9项，关于抑郁综合征的12项研究中有10项）表明过敏症与焦虑/情绪综合征之间存在关联。此外，似乎有许多潜在变量介导了过敏症与这两种精神现象之间的关系（例如，过敏症可能通过触发免疫系统和细胞因子来增加这些综合征的风险；过敏症可能通过鼻塞损害睡眠，进而加重精神症状；过敏症可能对认知功能产生负面影响并导致精神障碍）以及可能存在共同的遗传风险。作者对这些变量进行了回顾和讨论。
