一维确定性神经元传输的频散关系相位谱测量。
One-dimensional deterministic transport in neurons measured by dispersion-relation phase spectroscopy.
机构信息
Department of Mechanical Science and Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
出版信息
J Phys Condens Matter. 2011 Sep 21;23(37):374107. doi: 10.1088/0953-8984/23/37/374107. Epub 2011 Aug 23.
Abstract
We studied the active transport of intracellular components along neuron processes using a new method developed in our laboratory: dispersion-relation phase spectroscopy. This method is able to quantitatively map spatially the heterogeneous dynamics of the concentration field of the cargos at submicron resolution without the need for tracking individual components. The results in terms of density correlation function reveal that the decay rate is linear in wavenumber, which is consistent with a narrow Lorentzian distribution of cargo velocity.
摘要
我们使用我们实验室开发的一种新方法——弥散相关相位谱学，研究了细胞内成分沿神经元突起的主动运输。该方法能够在无需跟踪单个成分的情况下，以亚微米分辨率定量绘制货物浓度场的非均匀动力学图谱。从密度相关函数的结果来看，衰减率在波数上呈线性关系，这与货物速度的窄洛伦兹分布一致。
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