Kierasińska Magdalena, Donskow-Łysoniewska Katarzyna
Laboratory of Parasitology, General Karol Kaczkowski Military Institute of Hygiene and Epidemiology, Warsaw, Poland.
Cent Eur J Immunol. 2021;46(4):502-508. doi: 10.5114/ceji.2021.110314. Epub 2021 Nov 1.
It is debatable whether intestinal dysbiosis in autoimmune disease is a cause or a consequence of chronic inflammation, but it is known that intestinal dysbiosis in the course of the disease is accompanied by an increased number of pro-inflammatory lymphocytes in the Th17 population. Yet, little is known about the systemic implications of skin and even the intestinal microbiome for skin immunity and pathogenesis in psoriasis, which the most prevalent autoimmune disease in the Caucasian population. The pathogenesis of psoriasis is multifactorial with notable contributions from genetics and environmental factors (e.g. diet, drugs and infection). This article describes alterations in the microbiome and macrobiome, which are involved in immune regulation. The composition of the gut microbiome can dramatically affect immune development and affect susceptibility to diseases, especially autoimmune disorders such as psoriasis. Understanding the mechanisms of pathogenesis induced by the micro- and macrobiome may prove crucial for innovative future solutions in skin disease treatment.
自身免疫性疾病中的肠道菌群失调是慢性炎症的原因还是结果，这尚有争议，但已知在疾病过程中肠道菌群失调伴随着Th17群体中促炎淋巴细胞数量的增加。然而，对于皮肤乃至肠道微生物群对银屑病（白种人最常见的自身免疫性疾病）的皮肤免疫和发病机制的全身影响，人们知之甚少。银屑病的发病机制是多因素的，遗传学和环境因素（如饮食、药物和感染）起了显著作用。本文描述了参与免疫调节的微生物群和大微生物群的改变。肠道微生物群的组成可显著影响免疫发育，并影响对疾病的易感性，尤其是对银屑病等自身免疫性疾病。了解微生物群和大微生物群诱导发病的机制可能对皮肤病治疗的创新未来解决方案至关重要。
