Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indian J Dermatol Venereol Leprol. 2013 Jul;79 Suppl 7:S1-9. doi: 10.4103/0378-6323.115505.
Psoriasis is a chronic inflammatory papulosquamous disease characterized by multiple remissions and relapses. For long, it was believed to be primarily a disorder of keratinization. However, the successful use of traditional immunosupressants and newer immunomodulatory agents in the treatment of psoriasis led to the belief that psoriasis is primarily a disease of Th1 cell immune dysregulation. Recent developments have brought up several new findings such as the role of Th17 cells and evidence of skin barrier dysfunction in psoriasis, akin to atopic dermatitis. The present review aims to focus on these new developments and explain the pathogenesis of psoriasis on the basis of currently available information.
银屑病是一种慢性炎症性丘疹鳞屑病，其特征为多次缓解和复发。长期以来，人们认为它主要是一种角化病。然而，传统免疫抑制剂和新型免疫调节剂在银屑病治疗中的成功应用，使人们相信银屑病主要是 Th1 细胞免疫失调的疾病。最近的研究进展带来了一些新的发现，如 Th17 细胞的作用和银屑病皮肤屏障功能障碍的证据，类似于特应性皮炎。本综述旨在关注这些新的进展，并根据现有资料解释银屑病的发病机制。
