Ghosh D
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115.
Nucleic Acids Res. 1990 Apr 11;18(7):1749-56. doi: 10.1093/nar/18.7.1749.
Recent advances in the understanding of eukaryotic gene regulation have produced an extensive body of transcriptionally-related sequence information in the biological literature, and have created a need for computing structures that organize and manage this information. The 'relational model' represents an approach that is finding increasing application in the design of biological databases. This report describes the compilation of information regarding eukaryotic transcription factors, the organization of this information into five tables, the computational applications of the resultant relational database that are of theoretical as well as experimental interest, and possible avenues of further development.
对真核基因调控理解的最新进展在生物学文献中产生了大量与转录相关的序列信息,并且产生了对组织和管理这些信息的计算结构的需求。“关系模型”代表了一种在生物数据库设计中得到越来越广泛应用的方法。本报告描述了关于真核转录因子信息的汇编、将该信息组织成五个表的过程、所得关系数据库在理论和实验方面都感兴趣的计算应用,以及可能的进一步发展途径。