Lönroth H, Håkanson R, Lundell L, Sundler F
Department of Surgery, Sahlgren's Hospital, University of Gothenburg, Sweden.
Gut. 1990 Apr;31(4):383-8. doi: 10.1136/gut.31.4.383.
Histamine and chromogranin A-immunoreactive cells were studied in the mucosa of the human stomach. Cells reacting to both histamine and chromogranin A-antibodies (histamine containing endocrine cells), were demonstrated by double immunostaining and found to be restricted to the oxyntic mucosa. Histamine containing cells that did not stain with chromogranin A-antibodies were numerous throughout the stomach. Of the histamine immunoreactive cells in the oxyntic gland area 22% reacted with antibodies against chromogranin A. Histamine containing endocrine cells constituted 44% of the total number of endocrine cells in the oxyntic mucosa. These findings suggest that the histamine containing endocrine cells in the human stomach are identical with the so called enterochromaffin like cells.
对人胃黏膜中的组胺和嗜铬粒蛋白A免疫反应性细胞进行了研究。通过双重免疫染色证实了对组胺和嗜铬粒蛋白A抗体均有反应的细胞（含组胺的内分泌细胞），并发现其仅限于胃底黏膜。在整个胃中，不与嗜铬粒蛋白A抗体染色的含组胺细胞数量众多。在胃底腺区的组胺免疫反应性细胞中，22%与抗嗜铬粒蛋白A抗体发生反应。含组胺的内分泌细胞占胃底黏膜内分泌细胞总数的44%。这些发现表明，人胃中含组胺的内分泌细胞与所谓的肠嗜铬样细胞相同。
