Institut Curie, Centre de Recherche, Orsay, France.
Oncogene. 2012 Apr 5;31(14):1743-56. doi: 10.1038/onc.2011.363. Epub 2011 Aug 29.
The Hippo pathway, a signaling cascade that controls cell cycle progression, apoptosis and cell differentiation, has emerged as a fundamental regulator of many physiological and pathological processes. Recent studies have revealed a complex network of interactions directing Hippo pathway activity, and have connected this pathway with other key signaling pathways. Such crosstalk has uncovered novel roles for Hippo signaling, including regulation of TGFβ/SMAD and WNT/β-catenin pathways. This review highlights some of the recent findings in the Hippo field with an emphasis on how the Hippo pathway is integrated with other pathways to mediate diverse processes.
Hippo 通路是一个控制细胞周期进程、细胞凋亡和细胞分化的信号级联反应，已成为许多生理和病理过程的基本调节因子。最近的研究揭示了指导 Hippo 通路活性的复杂相互作用网络，并将该通路与其他关键信号通路联系起来。这种串扰揭示了 Hippo 信号的新作用，包括对 TGFβ/SMAD 和 WNT/β-catenin 通路的调节。本文重点介绍 Hippo 通路与其他通路整合以介导多种过程的方式，强调 Hippo 通路与其他通路的相互作用，突出 Hippo 领域的一些最新发现。
