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评价外周血中性粒细胞和单核细胞黏附分子 CD64、CD11b 和 CD62L 对新生儿感染的早期诊断价值。

Evaluation of adhesion molecules CD64, CD11b and CD62L in neutrophils and monocytes of peripheral blood for early diagnosis of neonatal infection.

机构信息

Department of Pediatrics, Dr Behçet Uz Children's Hospital, Alsancak, Izmir, Turkey.

出版信息

World J Pediatr. 2012 Feb;8(1):72-5. doi: 10.1007/s12519-011-0304-6. Epub 2011 Aug 27.

DOI:10.1007/s12519-011-0304-6
PMID:21874613
Abstract

BACKGROUND

This study was undertaken to assess the value of neutrophils CD11b, CD64, and CD62L for the early diagnosis of neonatal infection.

METHODS

Eighty-four neonates who were followed up for a suspected neonatal infection were included in this study. They were assigned into an infection group (n=49) and a non-infection group (n=35). Healthy neonates served as controls (n=35). A full sepsis screening was performed and neutrophil and monocyte expressions of CD11b, CD64 and CD62L were determined by flow cytometry.

RESULTS

The expressions of CD64 and CD11b were significantly enhanced in the infection group compared to the non-infective group and the controls.

CONCLUSIONS

CD64 expression on neutrophils and monocytes is a useful diagnostic marker for the early diagnosis of neonatal infection. Combination of CD64, CD11b and C reactive protein further enhances the sensitivity of the expression and its negative predictive value.

摘要

背景

本研究旨在评估中性粒细胞 CD11b、CD64 和 CD62L 对新生儿感染的早期诊断价值。

方法

本研究纳入了 84 例疑似新生儿感染的患儿。将其分为感染组（n=49）和非感染组（n=35）。健康新生儿作为对照组（n=35）。进行全面的脓毒症筛查，并通过流式细胞术检测中性粒细胞和单核细胞 CD11b、CD64 和 CD62L 的表达。

结果

感染组的 CD64 和 CD11b 表达明显高于非感染组和对照组。

结论

中性粒细胞和单核细胞 CD64 的表达是新生儿感染早期诊断的有用诊断标志物。联合检测 CD64、CD11b 和 C 反应蛋白可进一步提高表达的敏感性和阴性预测值。

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