Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul 152-703, South Korea.
World J Gastroenterol. 2011 Jul 28;17(28):3335-41. doi: 10.3748/wjg.v17.i28.3335.
To evaluate the relationship between hepatic fat infiltration and abdominal fat volume by using computed tomography (CT).
Three hundred and six patients who visited our obesity clinic between November 2007 and April 2008 underwent fat protocol CT scans. The age range of the patients was 19 to 79 years and the mean age was 49 years. The male to female ratio was 116:190. Liver and spleen attenuation measurements were taken with three regions of interests (ROIs) from the liver and two ROIs from the spleen. Hepatic attenuation indices (HAIs) were measured as follows: (1) hepatic parenchymal attenuation (CT(LP)); (2) liver to spleen attenuation ratio (LS ratio); and (3) difference between hepatic and splenic attenuation (LS(dif)). Abdominal fat volume was measured using a 3 mm slice CT scan starting at the level of the umbilicus and was automatically calculated by a workstation. Abdominal fat was classified into total fat (TF), visceral fat (VF), and subcutaneous fat (SF). We used a bivariate correlation method to assess the relationship between the three HAIs and TF, VF, and SF.
There were significant negative correlations between CT(LP), LS ratio, and LS(dif) with TF, VF, and SF, respectively. The CT(LP) showed a strong negative correlation with TF and VF (r = -0.415 and -0.434, respectively, P < 0.001). The correlation between CT(LP) and SF was less significant (r = -0.313, P < 0.001).
Fatty infiltration of the liver was correlated with amount of abdominal fat and VF was more strongly associated with fatty liver than SF.
利用计算机断层扫描（CT）评估肝脂肪浸润与腹部脂肪量的关系。
2007 年 11 月至 2008 年 4 月期间，我们肥胖诊所的 306 名患者接受了脂肪方案 CT 扫描。患者年龄在 19 岁至 79 岁之间，平均年龄为 49 岁。男女比例为 116:190。从肝脏的三个感兴趣区域（ROI）和脾脏的两个 ROI 测量肝脏和脾脏的衰减测量值。肝衰减指数（HAI）的测量如下：（1）肝实质衰减（CT（LP））；（2）肝脾衰减比（LS 比）；（3）肝脾衰减差值（LS(dif)）。从脐部水平开始，使用 3 毫米切片 CT 扫描测量腹部脂肪量，并通过工作站自动计算。腹部脂肪分为总脂肪（TF）、内脏脂肪（VF）和皮下脂肪（SF）。我们使用双变量相关方法评估三种 HAI 与 TF、VF 和 SF 之间的关系。
CT（LP）、LS 比和 LS(dif)与 TF、VF 和 SF 分别呈显著负相关。CT（LP）与 TF 和 VF 呈强负相关（r 分别为-0.415 和-0.434，均 P <0.001）。CT（LP）与 SF 的相关性较低（r = -0.313，P <0.001）。
肝脏脂肪浸润与腹部脂肪量相关，VF 与脂肪肝的相关性强于 SF。
