Laboratory of Functional Chemo-Systems UMR 7199, 74 Route du Rhin, 67401 Illkirch-Graffenstaden, France.
Bioorg Med Chem. 2012 Jan 15;20(2):571-82. doi: 10.1016/j.bmc.2011.07.048. Epub 2011 Jul 30.
Interest in cleavable linkers is growing due to the rapid development and expansion of chemical biology. The chemical constrains imposed by the biological conditions cause significant challenges for organic chemists. In this review we will present an overview of the cleavable linkers used in chemical biology classified according to their cleavage conditions by enzymes, nucleophilic/basic reagents, reducing agents, photo-irradiation, electrophilic/acidic reagents, organometallic and metal reagents, oxidizing reagents.
由于化学生物学的快速发展和扩展，人们对可裂解连接子的兴趣日益浓厚。生物条件所施加的化学限制给有机化学家带来了巨大的挑战。在这篇综述中，我们将根据酶、亲核/碱性试剂、还原剂、光辐射、亲电/酸性试剂、有机金属和金属试剂、氧化还原试剂等裂解条件，对化学生物学中使用的可裂解连接子进行分类概述。
