Orthopaedic Research Laboratory, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, the Netherlands.
J Orthop Res. 2012 Mar;30(3):364-70. doi: 10.1002/jor.21512. Epub 2011 Aug 22.
Femoral fractures within resurfacing implants have been associated with bone necrosis, possibly resulting from heat generated by cement polymerization. The amount of heat generated depends on cement mantle volume and type of cement. Using finite element analysis, the effect of cement type and volume on thermal necrosis was analyzed. Based on CT-data of earlier implantations, two different models were created: a thick mantle model, representing a low-viscosity "cement filling" technique, and a thin mantle model, representing a high viscosity "cement packing" technique. Six cement types were analyzed. The polymerization heat generation and its effect on bone necrosis were predicted. In the thin cement mantle models, no thermal necrosis was predicted. Thick cement mantle models produced thermal necrosis at the cement-bone interface depending on cement type. In the worst case, 6% of the bone at the cement-bone interface became necrotic, covering almost the entire cross-sectional area. The current findings suggest a potential thermal drawback of thick cement mantles, although it is unclear whether thermal bone necrosis significantly affects implant fixation or increases the fracture risk. Furthermore, our study showed distinct differences between the heat generated and resulting thermal damage caused by the various cement types.
翻修假体中的股骨骨折与骨坏死有关,这可能是由于骨水泥聚合产生的热量所致。产生的热量取决于水泥覆盖层的体积和水泥的类型。本研究采用有限元分析,研究了水泥类型和体积对热坏死的影响。基于早期植入物的 CT 数据,创建了两种不同的模型:一种是厚水泥覆盖层模型,代表低粘度的“水泥填充”技术;另一种是薄水泥覆盖层模型,代表高粘度的“水泥填充”技术。分析了 6 种不同的水泥类型。预测了聚合热的产生及其对骨坏死的影响。在薄水泥覆盖层模型中,没有预测到热坏死。厚水泥覆盖层模型会根据水泥类型在水泥-骨界面产生热坏死。在最坏的情况下,水泥-骨界面的 6%的骨头发生了坏死,几乎覆盖了整个横截面积。目前的研究结果表明,厚水泥覆盖层存在潜在的热缺陷,尽管尚不清楚热骨坏死是否会显著影响植入物固定或增加骨折风险。此外,我们的研究还显示了不同水泥类型产生的热量和由此产生的热损伤之间存在明显差异。