Institute on Aging and Department of Population Health Sciences, University of Wisconsin-Madison, USA.
Ann N Y Acad Sci. 2011 Aug;1231:23-34. doi: 10.1111/j.1749-6632.2011.06040.x.
Social isolation and poor sleep quality are independent predictors of poor health outcomes and increased biological risk for disease. We previously found in a small sample of older women that the presence of social ties compensated for poor sleep in associations with the inflammatory protein interleukin 6 (IL-6). The current study extended those findings to a national sample of middle-aged and older men and women. Using both subjective and objective sleep assessments, we found that in men, but not in women, social engagement moderated the association of subjective sleep complaints with both IL-6 and the soluble adhesion molecule E-selectin. Social engagement also moderated the link between sleep efficiency-assessed by actigraphy-and IL-6 levels in men, but not in women. These results extend our previous work and bolster the suggestion that positive psychological functioning may compensate for other risk factors in predicting advantageous profiles of biological risk in aging adults.
社会隔离和睡眠质量差是健康状况不佳和疾病生物学风险增加的独立预测因素。我们之前在一项针对老年女性的小样本研究中发现，社会关系的存在可以弥补睡眠不佳与炎症蛋白白细胞介素 6（IL-6）之间的关联。本研究将这些发现扩展到了一个全国性的中年和老年男性和女性样本中。使用主观和客观的睡眠评估，我们发现，在男性中，但不是在女性中，社会参与度调节了主观睡眠抱怨与 IL-6 和可溶性黏附分子 E-选择素之间的关联。社会参与度也调节了男性的睡眠效率（通过活动记录仪评估）与 IL-6 水平之间的联系，但在女性中则没有。这些结果扩展了我们之前的工作，并支持了积极的心理功能可能会弥补其他风险因素，从而预测老年成年人具有有利的生物学风险特征的观点。
