Top Institute Food and Nutrition, Wageningen, The Netherlands.
Physiol Behav. 2012 Jan 18;105(2):321-4. doi: 10.1016/j.physbeh.2011.08.015. Epub 2011 Aug 23.
Eating behavior changes under stress, i.e. during high HPA-axis activation.
Assessment of effects of high versus low HPA-axis activation on liking and wanting related brain signaling in relevant regions.
15 female subjects (21.5±0.4 years, BMI=22.2±0.4) completed fMRI scans on 2 days, in a fasted as well as a satiated condition on each day. The days were sorted by HPA-axis activation, resulting in two sufficiently separated HPA-axis states which were statistically confirmed (p<.05). During scans, subjects rated liking and wanting for food images; wanting indicated food choice for the subsequent meal. Energy-intake, hunger and fullness were additionally recorded.
Hunger changed significantly over the meal (p<.001). Energy intake was lower during the second meal (p<.001). Behavioral wanting was lower after breakfast (p<.01), behavioral liking did not change. During low HPA-activation, liking task related signaling (TRS) pre-meal in the anterior insula predicted behavioral liking, wanting TRS in the anterior insula, nucleus accumbens and thalamus predicted behavioral wanting. During high HPA-activation, these relationships were not present pre-meal, but post-meal behavioral liking was predicted in the nucleus accumbens and wanting in the caudate.
High HPA-axis activation disrupted and redirected the connection of behavioral liking/wanting with the specifically associated brain signaling in relevant regions.
在压力下，即高 HPA 轴激活期间，进食行为会发生变化。
评估高与低 HPA 轴激活对相关区域与喜好和欲望相关的大脑信号的影响。
15 名女性受试者（21.5±0.4 岁，BMI=22.2±0.4）在禁食和饱腹状态下，各在两天内完成 fMRI 扫描。根据 HPA 轴激活情况对两天进行排序，得到两个足够分离的 HPA 轴状态，并进行了统计学确认（p<.05）。在扫描过程中，受试者对食物图像的喜好和欲望进行评分；欲望表示随后用餐的食物选择。此外，还记录了能量摄入、饥饿感和饱腹感。
饥饿感在整个用餐过程中发生显著变化（p<.001）。第二餐的能量摄入较低（p<.001）。早餐后行为欲望较低（p<.01），行为喜好没有变化。在低 HPA 激活期间，餐前前岛叶的喜好任务相关信号（TRS）预测了行为喜好，前岛叶、伏隔核和丘脑的欲望 TRS 预测了行为欲望。在高 HPA 激活期间，这些关系在餐前不存在，但餐后的伏隔核与尾状核预测了行为喜好和欲望。
高 HPA 轴激活破坏并改变了与相关区域中特定相关的行为喜好/欲望的大脑信号的连接。
